| Revision as of 20:41, 19 December 2010 edit64.85.252.225 (talk) Added reference to CREA and Paul Segall as well are correctly stated the name of the imaging system that was developed in Timiras's lab. Refer to peer reviewed journals and CREA web site← Previous edit | Revision as of 20:41, 19 December 2010 edit undoRenamed user 5695569576f6b340 (talk | contribs)8,547 editsm Reverted edits by 64.85.252.225 (talk) to last revision by Crusio (HG)Next edit → | ||
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| Paola S. Timiras (born Paola Silvestri on July 21, 1923 Rome, Italy - September 12, 2008 Berkeley, California, USA) was an ] studying ]. | '''Paola S. Timiras''' (born Paola Silvestri on July 21, 1923 Rome, Italy - September 12, 2008 Berkeley, California, USA) was an ] studying ]. | ||
| ==Biography== | ==Biography== | ||
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| In 1954, she moved to Salt Lake City to pursue that line of inquiry in the pharmacology department at the ]. In 1955, she joined the ] physiology department as an assistant physiologist and was appointed to the faculty in 1958. She became a full professor in 1967.<ref name="UCB1"/> | In 1954, she moved to Salt Lake City to pursue that line of inquiry in the pharmacology department at the ]. In 1955, she joined the ] physiology department as an assistant physiologist and was appointed to the faculty in 1958. She became a full professor in 1967.<ref name="UCB1"/> | ||
| At UC Berkeley, Timiras studied the effects of caloric restriction on various hypothalamic nuclei, specifically the effects on cell density, ] immunoreactivity and insulin-like growth factor-1 (]) receptor immunoreactivity. |
At UC Berkeley, Timiras studied the effects of caloric restriction on various hypothalamic nuclei, specifically the effects on cell density, ] immunoreactivity and insulin-like growth factor-1 (]) receptor immunoreactivity. An ] system was developed in order to generate three-dimensional maps of the mouse hypothalamus.<ref name="NEL">{{Cite document |url=http://www.ncbi.nlm.nih.gov/pubmed/15990721?dopt=AbstractPlu8 |title=Caloric restriction reduces cell loss and maintains estrogen receptor-alpha immunoreactivity in the pre-optic hypothalamus of female B6D2F1 micem|author=Yaghmaie F, Saeed O, Garan SA, Freitag W, Timiras PS, Sternberg H. |date=June 26, 2005 |publisher=Neuro Endocrinol Lett. |postscript=<!--None-->}}</ref><ref name="EG">{{Cite document |url=http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%235032%232000%23999649990%23220575%23FLA%23&_cdi=5032&_pubType=J&_auth=y&_prev=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4ce0a658bd9d5dd8caa9ff9364727108 |title=Creating Three-Dimensional Neuronal Maps of the Mouse Hypothalamus Using an Automated Imaging Microscope System|author=Garan SA, Neudorf J, Tonkin J, McCook LR, Timiras PS. |date=December, 2000 |publisher=Experimental Gerontology |postscript=<!--None-->}}</ref> | ||
| In the 1960s, Timiras developed a course on the physiology of aging, one of the first such courses in the United States.<ref name="SCIMAG1"/> | In the 1960s, Timiras developed a course on the physiology of aging, one of the first such courses in the United States.<ref name="SCIMAG1"/> | ||
| In 2001 at age 78, Timiras became one of the founding members of the Center for Research and Education on Aging at the ]<ref name="UCB1"/> of which she served as the first chair.<ref name="CREA">{{cite web |url=http://crea.berkeley.edu/crea.shtml |title=Center for Research and Education on Aging |publisher=University of California, Berkeley}}</ref> | |||
| She contributed to or edited over 420 articles and 15 books before her death in 2008.<ref name="UCMemoriam1"/><ref name="UCB1">{{cite news | She contributed to or edited over 420 articles and 15 books before her death in 2008.<ref name="UCMemoriam1"/><ref name="UCB1">{{cite news | ||
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| {{Persondata <!-- Metadata: see ]. --> | {{Persondata <!-- Metadata: see ]. --> | ||
| | NAME = Timiras, Paola S. | | NAME = Timiras, Paola S. | ||
| | ALTERNATIVE NAMES = | | ALTERNATIVE NAMES = Silvestri, Paola | ||
| | SHORT DESCRIPTION = | | SHORT DESCRIPTION = American endocrinologist | ||
| | DATE OF BIRTH = | | DATE OF BIRTH = July 21, 1923 | ||
| | PLACE OF BIRTH = | | PLACE OF BIRTH = Rome, Italy | ||
| | DATE OF DEATH = | | DATE OF DEATH = September 12, 2008 | ||
| | PLACE OF DEATH = | | PLACE OF DEATH = Berkeley, CA, United States | ||
| }} | }} | ||
| {{DEFAULTSORT:Timiras, Paola S.}} | {{DEFAULTSORT:Timiras, Paola S.}} | ||
Revision as of 20:41, 19 December 2010
Paola S. Timiras (born Paola Silvestri on July 21, 1923 Rome, Italy - September 12, 2008 Berkeley, California, USA) was an endocrinologist studying stress.
Biography
Timiras obtained her medical degree from the University of Rome La Sapienza in 1947. She married Romanian diplomat Nicholas Timiras and then moved with him to Canada where she studied experimental medicine and surgery at the Université de Montréal, gained her doctorate in 1952. During her postdoctoral work at the University of Montreal her supervisor was the endocrinologist Hans Selye. One of Timiras's colleagues was Roger Guillemin.
Timiras performed her doctoral research at the University of Montreal in the lab of Hans Selye, who had developed the first theories about the body's hormonal responses to stress. At his suggestion, Timiras applied for and won a research fellowship that allowed her to work in his lab. There, she studied how stress influences the immune system through the effects of adrenocortical hormones. Before she finished her degree, the university hired her as an assistant professor.
In 1954, she moved to Salt Lake City to pursue that line of inquiry in the pharmacology department at the University of Utah. In 1955, she joined the University of California, Berkeley physiology department as an assistant physiologist and was appointed to the faculty in 1958. She became a full professor in 1967.
At UC Berkeley, Timiras studied the effects of caloric restriction on various hypothalamic nuclei, specifically the effects on cell density, estrogen receptor alpha immunoreactivity and insulin-like growth factor-1 (IGF-1) receptor immunoreactivity. An automated tissue image analysis system was developed in order to generate three-dimensional maps of the mouse hypothalamus.
In the 1960s, Timiras developed a course on the physiology of aging, one of the first such courses in the United States.
In 2001 at age 78, Timiras became one of the founding members of the Center for Research and Education on Aging at the University of California, Berkeley of which she served as the first chair.
She contributed to or edited over 420 articles and 15 books before her death in 2008.
Honors and awards
- 1970: President, Iota Sigma Pi, Association of Women Chemists
- 1974-1982: Vice-President and President, International Society of Psychoneuroendocrinology
- 1978-1982: President, International Society of Developmental Neuroscience
- 1984: Silver Award from the University of Chieti Medical School, Italy, for consultation on establishing courses on aging
- 1985: Gold Medal for Research Award, American Aging Association
- 1987: Andres Bello Decoration from Venezuela for contributing to international biomedical advancement
- 1990: Medal from University of Paris, XI, for promotion of joint Paris XI-UC Berkeley programs in biomedical sciences
- 1991: Medal from University of Pau (France), for fostering France-USA cultural relations
- 1996: Medal from University of Pisa (Italy), for fostering Italy-USA scientific/ biomedical relations
Publications
Articles
According to the Web of Science her 5 most cited papers are:
- Woolley DE, Timiras PS (1962). "The gonad-brain relationship: effects of female sex hormones on electroshock convulsions in the rat". Endocrinology. 70: 196–209. doi:10.1210/endo-70-2-196. PMID 14008291.
{{cite journal}}: Unknown parameter|month=ignored (help) - Terasawa E, Timiras PS (1968). "Electrical activity during the estrous cycle of the rat: cyclic changes in limbic structures". Endocrinology. 83 (2): 207–216. doi:10.1210/endo-83-2-207. PMID 4874282.
{{cite journal}}: Unknown parameter|month=ignored (help) - Woolley DE, Timiras PS (1962). "Estrous and circadian periodicity and electroshock convulsions in rats". The American Journal of Physiology. 202: 379–382. PMID 14008290.
{{cite journal}}: Unknown parameter|month=ignored (help) - Hudson DB, Valcana T, Bean G, Timiras PS (1976). "Glutamic Acid - Strong candidate as neurotransmitter of cerebellar granule cell". Neurochemical Research. 1 (1): 73–81. doi:10.1007/BF00965633.
{{cite journal}}: Cite has empty unknown parameter:|month=(help)CS1 maint: multiple names: authors list (link) - Brizzee KR, Sherwood N, Timiras PS (1968). "A comparison of cell populations at various depth levels in cerebral cortex of young adult and aged Long-Evans rats". Journal of Gerontology. 23 (3): 289–97. PMID 5663608.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
Books
- Physiological Basis of Aging And Geriatrics by Paola S. Timiras, August 2007 4th edition
- Stress, Adaptation, Longevite by Paola S. Timiras, January 2004
- Physiological Basis of Aging and Geriatrics, by Paola S. Timiras (Editor), September 2002 3rd edition
- Studies of Aging : Lab Manual, by Paola S. Timiras (Editor), Hal Sternberg (Editor), September 1999
- Genetic Aberrancies and Neurodegenerative Disorders, by Paola S. Timiras (Editor), E. Edward Bittar (Editor), Mark P. Mattson (Editor), October 1998
- Advances in Cell Aging and Gerontology : The Aging Brain, by Paola S. Timiras (Editor), E. Edward Bittar (Editor), Mark P. Mattson (Editor), James, W. Geddes (Editor), March 1998
- Brain Plasticity : Development and Aging, by Paola S. Timiras (Editor), Antonia Vernadakis (Editor), Guido Filogamo (Editor), Alain M. Privat (Editor), Fulvia Gremo (Editor), December 1997
- Advances in Cell Aging and Gerontology : Some Aspects of the Aging Process, by Paola S. Timiras (Editor), E. Edward Bittar (Editor), October 1996
- Hormones and Aging, by Paola S. Timiras, Antonia Vernadakis (Editor), Wilbur D. Quay, April 1995
- Physiological Basis of Aging and Geriatrics, by Paola S. Timiras (Editor), October 1994 2nd edition
- Plasticity and Regeneration of the Nervous System, by Paola S. Timiras, Ezio Giacobini (Editor), Alain Privat, December 1991
- Handbook of Human Growth and Developmental Biology : Developmental Biology of Organs and Systems Part A Muscle, Blood, and Immunity, by Paola S. Timiras (Editor), Esmail Meisami, January 1991
- Handbook of Human Growth and Developmental Biology : Endocrines,Sexual Development, Growth, Nutrition, and Metabolism/Part B Growth, Nutrition, and, by Paola S. Timiras (Editor), Esmial Meisami, February 1990
- Handbook of Human Growth and Developmental Biology : Endocrines, Sexual Development, Growth, Nutrition, and Metabolism/Part A Endocrines and Sexual, by Paola S. Timiras (Editor), Esmail Meisami, October 1989
- Handbook of Human Growth and Developmental Biology, Part B : Sensory, Motor, and Integrative Development, by Paola S. Timiras (Editor), Esmail Meisami, October 198
- Handbook of Human Growth and Development, Part A, Developmental Neurobiology, by Paola S. Timiras (Editor), Esmail Meisami ,September 1988
- Model Systems of Development and Aging of the Nervous System, by Paola S. Timiras, Jean M. Lauder, Antonia Vernadakis, Alain Privat, Gi, August 1987,
- A Stereotaxic Atlas of the Developing Rat Brain, by Paola S. Timiras, Nancy Sherwood, January 1970
References
- Mary Rourke (Sep 23, 2008). "Paola Timiras, 1923 - 2008; Researcher studied aging" (Document). Los Angeles Times.
{{cite document}}: Unknown parameter|url=ignored (help) - Patricia Yollin (September 20, 2008). "Paola Timiras, UC expert on aging, dies" (Document). San Francisco Chronicle.
{{cite document}}: Unknown parameter|url=ignored (help) - ^ "In Memoriam: Paola S. Timiras". Retrieved 2010-05-01.
- ^ Ingfei Chen (December 04, 2002). "Ageless Activist" (Document). Science.
{{cite document}}: Check date values in:|date=(help); Unknown parameter|url=ignored (help) - ^ Sanders, Media Relations, Bob (2008-09-17). "Paola Timiras, researcher on aging, dies at 85". UC Berkeley News. Retrieved 2010-05-01.
- Yaghmaie F, Saeed O, Garan SA, Freitag W, Timiras PS, Sternberg H. (June 26, 2005). "Caloric restriction reduces cell loss and maintains estrogen receptor-alpha immunoreactivity in the pre-optic hypothalamus of female B6D2F1 micem" (Document). Neuro Endocrinol Lett.
{{cite document}}: Unknown parameter|url=ignored (help)CS1 maint: multiple names: authors list (link) - Garan SA, Neudorf J, Tonkin J, McCook LR, Timiras PS. (December, 2000). "Creating Three-Dimensional Neuronal Maps of the Mouse Hypothalamus Using an Automated Imaging Microscope System" (Document). Experimental Gerontology.
{{cite document}}: Check date values in:|date=(help); Unknown parameter|url=ignored (help)CS1 maint: multiple names: authors list (link) - "Center for Research and Education on Aging". University of California, Berkeley.