| Revision as of 14:15, 19 December 2024 editMo18ekula (talk | contribs)260 edits ←Created page with '{{Infobox drug | drug_name = Mcn 5707 | image = Mcn 5707.svg | width = 250px | caption = <!-- Clinical data --> | pronounce = | tradename = | Drugs.com = | MedlinePlus = | licence_CA = | licence_EU = | DailyMedID = | licence_US = | pregnancy_AU = | pregnancy_category = | dependency_liability = | addiction_liability = | routes_of_administration = | class = | ATC_prefix = | ATC_suffix = <!-- Legal status --> | legal_status = <!-- Pharmaco...'Tag: Disambiguation links added |
Latest revision as of 16:36, 25 December 2024 edit undoRodw (talk | contribs)Autopatrolled, Event coordinators, Extended confirmed users, New page reviewers, Pending changes reviewers, Rollbackers773,834 editsm Disambiguating links to McNeil (link changed to McNeil Consumer Healthcare) using DisamAssist. |
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{{cs1 config|name-list-style=vanc|display-authors=6}} |
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{{Infobox drug |
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{{Infobox drug |
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| drug_name = Mcn 5707 |
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| drug_name = Mcn 5707 |
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| image = Mcn 5707.svg |
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| image = Mcn 5707.svg |
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| width = 250px |
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| width = 250px |
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| caption = |
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| caption = |
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<!-- Clinical data --> |
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<!-- Clinical data --> |
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| class = |
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| class = |
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| ATC_prefix = |
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| ATC_prefix = |
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| ATC_suffix = |
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| ATC_suffix = |
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<!-- Legal status --> |
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<!-- Legal status --> |
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| legal_status = |
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| legal_status = |
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<!-- Pharmacokinetic data --> |
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<!-- Pharmacokinetic data --> |
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| elimination_half-life = |
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| elimination_half-life = |
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| duration_of_action = |
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| duration_of_action = |
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| excretion = |
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| excretion = |
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<!-- Identifiers --> |
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<!-- Identifiers --> |
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| CAS_number = 96795-88-9 |
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| CAS_number = 96795-88-9 |
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| CAS_number2 = 109214-56-4 |
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| index2_label = hydrobromide |
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| CAS_supplemental = |
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| CAS_supplemental = |
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| PubChem = 126059 |
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| PubChem = 126059 |
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| KEGG = |
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| ChEBI = |
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| ChEBI = |
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| ChEMBL = |
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| ChEMBL = 1743803 |
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| NIAID_ChemDB = |
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| PDB_ligand = |
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| PDB_ligand = |
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| synonyms = |
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| synonyms = McN-5707 |
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<!--Chemical data--> |
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<!--Chemical data--> |
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| StdInChIKey = KWMNBUDYCCTHHL-SJLPKXTDSA-N |
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| StdInChIKey = KWMNBUDYCCTHHL-SJLPKXTDSA-N |
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}} |
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}} |
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Mcn 5707 is a ] agent designated for the treatment of depression. It was developed by ] of ] (now Johnson & Johnson) in the 1980s.<ref>{{cite journal | vauthors = Maryanoff BE, Shank RP, Gardocki JF | date = 1986 | title = McN-5707 and McN-5652-Z | journal = Drugs of the Future | volume = 11 | issue = 1 | pages = 18 | doi = 10.1358/dof.1986.011.01.51629 }}</ref><ref name="pmid6747993">{{cite journal | vauthors = Maryanoff BE, McComsey DF, Castanzo MJ, Setler PE, Gardocki JF, Shank RP, Schneider CR | title = Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin | journal = Journal of Medicinal Chemistry | volume = 27 | issue = 8 | pages = 943–6 | date = August 1984 | pmid = 6747993 | doi = 10.1021/jm00374a001 }}</ref> |
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Mcn 5707 is a SNDRI agent for the treatment of depression. It was developed by ] of ] (now Johnson & Johnson) in the 1980’s. |
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For related agents, see ], ], ], ] & ]. |
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The Ki numbers quoted (24b) are: DAT 35.9nM, NET: 1.9nM and SERT = 8.5nM. |
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Ref:<ref> Maryanoff, B. E., Shank, R. P., Gardocki, J. F. (1986). "McN-5707 and McN-5652-Z". Drugs of the Future. 11 (1): 18. doi:10.1358/dof.1986.011.01.51629. </ref><ref> Maryanoff, BE; et al.; Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin. J Med Chem 1984, 27, 8, 943.</ref><ref>Bruce E. Maryanoff, US4719216 (1988 to Janssen Pharmaceuticals Inc).</ref> |
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== References == |
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{{reflist}} |
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== References == |
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== References == |
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