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Highway110 started out as '''U.S. Route 110''', a {{convert|40|mi|km|adj=on}} long north–south ] located entirely within Wisconsin. The southern terminus of the route was at ] (now the intersection of ] and ]) in ]. The northern terminus was at ] (now the northern terminus of the ]/Highway110 concurrency) east of ].
Highway 110 started out as '''U.S. Route 110''' ('''US 110'''), a {{convert|40|mi|km|adj=on}} long south-to-north ] located entirely within Wisconsin. The southern terminus of the route was at ] (now the ] of ] and ]) in ]. The northern terminus was at ] (now the northern terminus of the ]/Highway 110 concurrency) east of ].
US110 was deleted in 1939<ref name="WH1"/> and subsequently replaced with WIS110. Due to a series of extensions and truncations in the 70 years since, however, WIS110 is no longer designated on most of the former routing of US110. Today, what was once US110 is now US45 from Oshkosh to ], CTHII from Winchester to US10 southeast of Fremont, and WIS110 from US10 to WIS96 east of Fremont.
US 110 was deleted in 1939<ref name="WH1"/> and subsequently replaced with WIS 110. Due to a series of extensions and truncations in the 70 years since, however, WIS 110 is no longer designated on most of the former routing of US 110. Today, what was once US 110 is now US 45 from Oshkosh to ], CTH-II from Winchester to US 10 southeast of Fremont, and WIS 110 from US 10 to WIS 96 east of Fremont.
The highway begins at an intersection with US 10 and WIS-96 southeast of Fremont. It heads north from US 10 for about half a mile before turning westward. It passes through Fremont and heads to the northwest before turning to the south toward US 10 and WIS-49.
The highway then runs concurrently to the north with US 10 and WIS-49 for about 5 miles (8.0 km). It then splits off and heads northward into Weyauwega. After it leaves the city, the highway continues to the northwest, where it will meet with WIS-22 and WIS-54. It runs concurrently to the north along both highways before WIS-54 splits off. WIS-110 and WIS-54 continue concurrently northward, passing through Manawa. North of Manawa, the highways split and WIS-110 continues to the north. Further along, it enters Marion, where it terminates at US 45.
Highway 110 started out as U.S. Route 110 (US 110), a 40-mile (64 km) long south-to-north U.S. highway located entirely within Wisconsin. The southern terminus of the route was at US 41 (now the intersection of US 45 and Highway 76) in Oshkosh. The northern terminus was at US 10 (now the northern terminus of the Highway 96/Highway 110 concurrency) east of Fremont, Wisconsin.
US 110 was deleted in 1939 and subsequently replaced with WIS 110. Due to a series of extensions and truncations in the 70 years since, however, WIS 110 is no longer designated on most of the former routing of US 110. Today, what was once US 110 is now US 45 from Oshkosh to Winchester, CTH-II from Winchester to US 10 southeast of Fremont, and WIS 110 from US 10 to WIS 96 east of Fremont.
State Trunk Highway 110
US 10 / WIS 96 / CTH-II in Fremont
US 10 / WIS 49 in Fremont
US 45 in Marion
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U.S. Highway 110
US 10/WIS-96
WIS-22/WIS-54
WIS-161/WIS-22
US 45