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{{Infobox_gene}} |
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{{Infobox_gene}} |
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'''Single Ig IL-1-related receptor''' is a ] that in humans is encoded by the ''SIGIRR'' ].<ref name="pmid10346978">{{cite journal | author = Thomassen E, Renshaw BR, Sims JE | title = Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily | journal = Cytokine | volume = 11 | issue = 6 | pages = 389–99 |date=Jul 1999 | pmid = 10346978 | pmc = | doi = 10.1006/cyto.1998.0452 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59307| accessdate = }}</ref> |
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'''Single Ig IL-1-related receptor''' is a ] that in humans is encoded by the ''SIGIRR'' ].<ref name="pmid10346978">{{cite journal | vauthors = Thomassen E, Renshaw BR, Sims JE | title = Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily | journal = Cytokine | volume = 11 | issue = 6 | pages = 389–99 |date=Jul 1999 | pmid = 10346978 | pmc = | doi = 10.1006/cyto.1998.0452 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59307| accessdate = }}</ref> |
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It has been observed to modulate immune responses, colonic epithelial homeostasis and ].<ref name="pmid12925853">{{cite journal | author = Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X | title = SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling | journal = Nat. Immunol. | volume = 4 | issue = 9 | pages = 920–7 |date=September 2003 | pmid = 12925853 | doi = 10.1038/ni968 }}</ref><ref name="pmid17398123">{{cite journal | author = Xiao H, Gulen MF, Qin J, Yao J, Bulek K, Kish D, Altuntas CZ, Wald D, Ma C, Zhou H, Tuohy VK, Fairchild RL, de la Motte C, Cua D, Vallance BA, Li X | title = The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis | journal = Immunity | volume = 26 | issue = 4 | pages = 461–75 |date=April 2007 | pmid = 17398123 | doi = 10.1016/j.immuni.2007.02.012 }}</ref> |
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It has been observed to modulate immune responses, colonic epithelial homeostasis and ].<ref name="pmid12925853">{{cite journal | vauthors = Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X | title = SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling | journal = Nat. Immunol. | volume = 4 | issue = 9 | pages = 920–7 |date=September 2003 | pmid = 12925853 | doi = 10.1038/ni968 }}</ref><ref name="pmid17398123">{{cite journal | vauthors = Xiao H, Gulen MF, Qin J, Yao J, Bulek K, Kish D, Altuntas CZ, Wald D, Ma C, Zhou H, Tuohy VK, Fairchild RL, de la Motte C, Cua D, Vallance BA, Li X | title = The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis | journal = Immunity | volume = 26 | issue = 4 | pages = 461–75 |date=April 2007 | pmid = 17398123 | doi = 10.1016/j.immuni.2007.02.012 }}</ref> |
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==Interactions== |
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==Interactions== |
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SIGIRR has been shown to ] with ].<ref name="pmid12925853"/> |
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SIGIRR has been shown to ] with ].<ref name="pmid12925853">{{cite journal | author = Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X | title = SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling | journal = Nat. Immunol. | volume = 4 | issue = 9 | pages = 920–7 |date=September 2003 | pmid = 12925853 | doi = 10.1038/ni968 }}</ref> |
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==References== |
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==References== |
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==Further reading== |
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==Further reading== |
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{{refbegin | 2}} |
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*{{cite journal | author=Du X, Poltorak A, Wei Y, Beutler B |title=Three novel mammalian toll-like receptors: gene structure, expression, and evolution. |journal=Eur. Cytokine Netw. |volume=11 |issue= 3 |pages= 362–71 |year= 2000 |pmid= 11022119 |doi= }} |
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*{{cite journal | vauthors=Du X, Poltorak A, Wei Y, Beutler B |title=Three novel mammalian toll-like receptors: gene structure, expression, and evolution. |journal=Eur. Cytokine Netw. |volume=11 |issue= 3 |pages= 362–71 |year= 2000 |pmid= 11022119 |doi= }} |
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*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} |
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*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} |
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*{{cite journal |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }} |
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*{{cite journal |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }} |
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*{{cite journal |vauthors=Qin J, Qian Y, Yao J, etal |title=SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms. |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 25233–41 |year= 2005 |pmid= 15866876 |doi= 10.1074/jbc.M501363200 }} |
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*{{cite journal |vauthors=Qin J, Qian Y, Yao J, etal |title=SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms. |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 25233–41 |year= 2005 |pmid= 15866876 |doi= 10.1074/jbc.M501363200 }} |
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It has been observed to modulate immune responses, colonic epithelial homeostasis and tumorigenesis.
