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Evobrutinib: Difference between revisions

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==References== ==References==
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Revision as of 15:38, 24 December 2024

Pharmaceutical compound
Evobrutinib
Legal status
Legal status
  • Investigational
Identifiers
CAS Number
PubChem CID
DrugBank
UNII
KEGG
Chemical and physical data
FormulaC25H27N5O2
Molar mass429.524 g·mol
3D model (JSmol)
SMILES
  • C=CC(=O)N1CCC(CC1)CNC2=NC=NC(=C2C3=CC=C(C=C3)OC4=CC=CC=C4)N

Evobrutinib is an experimental drug being studied for the treatment of encephalomyelitis and multiple sclerosis. It is an inhibitor of Bruton's tyrosine kinase.

References

  1. "Evobrutinib". AdisInsight.
  2. Montalban, Xavier; Piasecka-Stryczynska, Karolina; Kuhle, Jens; Benkert, Pascal; Arnold, Douglas L.; Weber, Martin S.; Seitzinger, Andrea; Guehring, Hans; Shaw, Jamie; Tomic, Davorka; Hyvert, Yann; Harlow, Danielle E.; Dyroff, Martin; Wolinsky, Jerry S. (2024). "Efficacy and safety results after >3.5 years of treatment with the Bruton's tyrosine kinase inhibitor evobrutinib in relapsing multiple sclerosis: Long-term follow-up of a Phase II randomised clinical trial with a cerebrospinal fluid sub-study". Multiple Sclerosis Journal. 30 (4–5): 558–570. doi:10.1177/13524585241234783. PMC 11080380. PMID 38436271.
  3. Montalban, Xavier; Vermersch, Patrick; Arnold, Douglas L.; Bar-Or, Amit; Cree, Bruce A C.; Cross, Anne H.; Kubala Havrdova, Eva; Kappos, Ludwig; Stuve, Olaf; Wiendl, Heinz; Wolinsky, Jerry S.; Dahlke, Frank; Le Bolay, Claire; Shen Loo, Li; Gopalakrishnan, Sathej; Hyvert, Yann; Javor, Andrija; Guehring, Hans; Tenenbaum, Nadia; Tomic, Davorka (2024). "Safety and efficacy of evobrutinib in relapsing multiple sclerosis (EvolutionRMS1 and evolutionRMS2): Two multicentre, randomised, double-blind, active-controlled, phase 3 trials". The Lancet Neurology. 23 (11): 1119–1132. doi:10.1016/S1474-4422(24)00328-4. PMID 39307151.
  4. "Evobrutinib". Multiple Sclerosis Trust.
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