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Revision as of 09:52, 27 May 2008 editNick (talk | contribs)Edit filter managers, Administrators22,291 editsm moved SIGIRR (gene) to SIGIRR over redirect← Previous edit Revision as of 15:40, 11 June 2008 edit undoDOI bot (talk | contribs)44,709 editsm Citation maintenance. You can use this bot yourself! Please report any bugs.Next edit →
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*{{cite journal | author=Thomassen E, Renshaw BR, Sims JE |title=Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. |journal=Cytokine |volume=11 |issue= 6 |pages= 389-99 |year= 1999 |pmid= 10346978 |doi= 10.1006/cyto.1998.0452 }} *{{cite journal | author=Thomassen E, Renshaw BR, Sims JE |title=Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. |journal=Cytokine |volume=11 |issue= 6 |pages= 389–99 |year= 1999 |pmid= 10346978 |doi= 10.1006/cyto.1998.0452 }}
*{{cite journal | author=Du X, Poltorak A, Wei Y, Beutler B |title=Three novel mammalian toll-like receptors: gene structure, expression, and evolution. |journal=Eur. Cytokine Netw. |volume=11 |issue= 3 |pages= 362-71 |year= 2000 |pmid= 11022119 |doi= }} *{{cite journal | author=Du X, Poltorak A, Wei Y, Beutler B |title=Three novel mammalian toll-like receptors: gene structure, expression, and evolution. |journal=Eur. Cytokine Netw. |volume=11 |issue= 3 |pages= 362–71 |year= 2000 |pmid= 11022119 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }} *{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Wald D, Qin J, Zhao Z, ''et al.'' |title=SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. |journal=Nat. Immunol. |volume=4 |issue= 9 |pages= 920-7 |year= 2003 |pmid= 12925853 |doi= 10.1038/ni968 }} *{{cite journal | author=Wald D, Qin J, Zhao Z, ''et al.'' |title=SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. |journal=Nat. Immunol. |volume=4 |issue= 9 |pages= 920–7 |year= 2003 |pmid= 12925853 |doi= 10.1038/ni968 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }} *{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} *{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Polentarutti N, Rol GP, Muzio M, ''et al.'' |title=Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. |journal=Eur. Cytokine Netw. |volume=14 |issue= 4 |pages= 211-8 |year= 2004 |pmid= 14715412 |doi= }} *{{cite journal | author=Polentarutti N, Rol GP, Muzio M, ''et al.'' |title=Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. |journal=Eur. Cytokine Netw. |volume=14 |issue= 4 |pages= 211–8 |year= 2004 |pmid= 14715412 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }} *{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Qin J, Qian Y, Yao J, ''et al.'' |title=SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms. |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 25233-41 |year= 2005 |pmid= 15866876 |doi= 10.1074/jbc.M501363200 }} *{{cite journal | author=Qin J, Qian Y, Yao J, ''et al.'' |title=SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms. |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 25233–41 |year= 2005 |pmid= 15866876 |doi= 10.1074/jbc.M501363200 }}
}} }}
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Revision as of 15:40, 11 June 2008

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SIGIRR
Identifiers
AliasesSIGIRR, TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, IL-1R8, single Ig and TIR domain containing
External IDsOMIM: 605478; MGI: 1344402; HomoloGene: 36399; GeneCards: SIGIRR; OMA:SIGIRR - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)
Chromosome 11 (human)Genomic location for SIGIRRGenomic location for SIGIRR
Band11p15.5Start405,716 bp
End417,455 bp
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)
Chromosome 7 (mouse)Genomic location for SIGIRRGenomic location for SIGIRR
Band7|7 F5Start140,671,088 bp
End140,680,485 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • mucosa of transverse colon

  • right lobe of liver

  • right uterine tube

  • apex of heart

  • olfactory zone of nasal mucosa

  • spleen

  • body of stomach

  • C1 segment

  • left uterine tube
Top expressed in
  • yolk sac

  • right kidney

  • proximal tubule

  • human kidney

  • epithelium of small intestine

  • thymus

  • intestinal villus

  • crypt of lieberkuhn of small intestine

  • ileum

  • submandibular gland
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

59307

24058

Ensembl

ENSG00000185187

ENSMUSG00000025494

UniProt

Q6IA17

Q9JLZ8

RefSeq (mRNA)

NM_001135053
NM_001135054
NM_021805

NM_023059
NM_001355055

RefSeq (protein)

NP_001128525
NP_001128526
NP_068577

NP_075546
NP_001341984

Location (UCSC)Chr 11: 0.41 – 0.42 MbChr 7: 140.67 – 140.68 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, also known as SIGIRR, is a human gene.

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References

  1. ^ GRCh38: Ensembl release 89: ENSG00000185187Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000025494Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain".

Further reading

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