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| '''Single Ig IL-1-related receptor''' is a ] that in humans is encoded by the ''SIGIRR'' ].<ref name="pmid10346978">{{cite journal | author = Thomassen E, Renshaw BR, Sims JE | title = Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily | journal = Cytokine | volume = 11 | issue = 6 | pages = 389–99 | year = 1999 | month = Jul | pmid = 10346978 | pmc = | doi = 10.1006/cyto.1998.0452 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59307| accessdate = }}</ref> |
'''Single Ig IL-1-related receptor''' is a ] that in humans is encoded by the ''SIGIRR'' ].<ref name="pmid10346978">{{cite journal | author = Thomassen E, Renshaw BR, Sims JE | title = Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily | journal = Cytokine | volume = 11 | issue = 6 | pages = 389–99 | year = 1999 | month = Jul | pmid = 10346978 | pmc = | doi = 10.1006/cyto.1998.0452 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59307| accessdate = }}</ref> | ||
| It has been observed to modulate immune responses, colonic epithelial homeostasis and ].<ref name="pmid12925853">{{cite journal | author = Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X | title = SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling | journal = Nat. Immunol. | volume = 4 | issue = 9 | pages = 920–7 | year = 2003 | month = September | pmid = 12925853 | doi = 10.1038/ni968 }}</ref><ref name="pmid17398123">{{cite journal | author = Xiao H, Gulen MF, Qin J, Yao J, Bulek K, Kish D, Altuntas CZ, Wald D, Ma C, Zhou H, Tuohy VK, Fairchild RL, de la Motte C, Cua D, Vallance BA, Li X | title = The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis | journal = Immunity | volume = 26 | issue = 4 | pages = 461–75 | year = 2007 | month = April | pmid = 17398123 | doi = 10.1016/j.immuni.2007.02.012 }}</ref> | |||
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| ==Interactions== | ==Interactions== | ||
| SIGIRR has been shown to ] with ].<ref name=pmid12925853>{{cite journal | |
SIGIRR has been shown to ] with ].<ref name="pmid12925853">{{cite journal | author = Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X | title = SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling | journal = Nat. Immunol. | volume = 4 | issue = 9 | pages = 920–7 | year = 2003 | month = September | pmid = 12925853 | doi = 10.1038/ni968 }}</ref> | ||
| ==References== | ==References== | ||
| {{reflist}} | {{reflist}} | ||
| ==Further reading== | ==Further reading== | ||
| {{refbegin | 2}} | {{refbegin | 2}} | ||
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| *{{cite journal | author=Du X, Poltorak A, Wei Y, Beutler B |title=Three novel mammalian toll-like receptors: gene structure, expression, and evolution. |journal=Eur. Cytokine Netw. |volume=11 |issue= 3 |pages= 362–71 |year= 2000 |pmid= 11022119 |doi= }} | *{{cite journal | author=Du X, Poltorak A, Wei Y, Beutler B |title=Three novel mammalian toll-like receptors: gene structure, expression, and evolution. |journal=Eur. Cytokine Netw. |volume=11 |issue= 3 |pages= 362–71 |year= 2000 |pmid= 11022119 |doi= }} | ||
| *{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
| *{{cite journal | author=Wald D, Qin J, Zhao Z, ''et al.'' |title=SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. |journal=Nat. Immunol. |volume=4 |issue= 9 |pages= 920–7 |year= 2003 |pmid= 12925853 |doi= 10.1038/ni968 }} | |||
| *{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }} | *{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }} | ||
| *{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | *{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
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| *{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | *{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
| *{{cite journal | author=Qin J, Qian Y, Yao J, ''et al.'' |title=SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms. |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 25233–41 |year= 2005 |pmid= 15866876 |doi= 10.1074/jbc.M501363200 }} | *{{cite journal | author=Qin J, Qian Y, Yao J, ''et al.'' |title=SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms. |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 25233–41 |year= 2005 |pmid= 15866876 |doi= 10.1074/jbc.M501363200 }} | ||
| }} | |||
| {{refend}} | {{refend}} | ||
| {{gene-11-stub}} | {{gene-11-stub}} | ||
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Revision as of 03:21, 22 August 2012
 | This article is an orphan, as no other articles link to it. Please introduce links to this page from related articles; try the Find link tool for suggestions. (February 2009) |
Template:PBB Single Ig IL-1-related receptor is a protein that in humans is encoded by the SIGIRR gene.
It has been observed to modulate immune responses, colonic epithelial homeostasis and tumorigenesis.
Interactions
SIGIRR has been shown to interact with TRAF6.
References
- Thomassen E, Renshaw BR, Sims JE (1999). "Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily". Cytokine. 11 (6): 389–99. doi:10.1006/cyto.1998.0452. PMID 10346978.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - "Entrez Gene: SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain".
- ^ Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X (2003). "SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling". Nat. Immunol. 4 (9): 920–7. doi:10.1038/ni968. PMID 12925853.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - Xiao H, Gulen MF, Qin J, Yao J, Bulek K, Kish D, Altuntas CZ, Wald D, Ma C, Zhou H, Tuohy VK, Fairchild RL, de la Motte C, Cua D, Vallance BA, Li X (2007). "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis". Immunity. 26 (4): 461–75. doi:10.1016/j.immuni.2007.02.012. PMID 17398123.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
Further reading
- Du X, Poltorak A, Wei Y, Beutler B (2000). "Three novel mammalian toll-like receptors: gene structure, expression, and evolution". Eur. Cytokine Netw. 11 (3): 362–71. PMID 11022119.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Polentarutti N, Rol GP, Muzio M; et al. (2004). "Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR". Eur. Cytokine Netw. 14 (4): 211–8. PMID 14715412.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Qin J, Qian Y, Yao J; et al. (2005). "SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms". J. Biol. Chem. 280 (26): 25233–41. doi:10.1074/jbc.M501363200. PMID 15866876.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
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