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SIGIRR
Identifiers
Aliases	SIGIRR, TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, IL-1R8, single Ig and TIR domain containing
External IDs	OMIM: 605478; MGI: 1344402; HomoloGene: 36399; GeneCards: SIGIRR; OMA:SIGIRR - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.5 Start 405,716 bp End 417,455 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F5 Start 140,671,088 bp End 140,680,485 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte mucosa of transverse colon right lobe of liver right uterine tube apex of heart olfactory zone of nasal mucosa spleen body of stomach C1 segment left uterine tube Top expressed in yolk sac right kidney proximal tubule human kidney epithelium of small intestine thymus intestinal villus crypt of lieberkuhn of small intestine ileum submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane membrane plasma membrane Biological process negative regulation of cytokine-mediated signaling pathway acute-phase response negative regulation of DNA-binding transcription factor activity signal transduction negative regulation of lipopolysaccharide-mediated signaling pathway cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 59307 24058 Ensembl ENSG00000185187 ENSMUSG00000025494 UniProt Q6IA17 Q9JLZ8 RefSeq (mRNA) NM_001135053 NM_001135054 NM_021805 NM_023059 NM_001355055 RefSeq (protein) NP_001128525 NP_001128526 NP_068577 NP_075546 NP_001341984 Location (UCSC) Chr 11: 0.41 – 0.42 Mb Chr 7: 140.67 – 140.68 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Single Ig IL-1-related receptor is a protein that in humans is encoded by the SIGIRR gene.

It has been observed to modulate immune responses, colonic epithelial homeostasis and tumorigenesis.

Interactions

SIGIRR has been shown to interact with TRAF6.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000185187 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000025494 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Thomassen E, Renshaw BR, Sims JE (Jul 1999). "Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily". Cytokine. 11 (6): 389–99. doi:10.1006/cyto.1998.0452. PMID 10346978.
6. "Entrez Gene: SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain".
7. ^ Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X (September 2003). "SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling". Nat. Immunol. 4 (9): 920–7. doi:10.1038/ni968. PMID 12925853. S2CID 25246605.
8. Xiao H, Gulen MF, Qin J, Yao J, Bulek K, Kish D, Altuntas CZ, Wald D, Ma C, Zhou H, Tuohy VK, Fairchild RL, de la Motte C, Cua D, Vallance BA, Li X (April 2007). "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis". Immunity. 26 (4): 461–75. doi:10.1016/j.immuni.2007.02.012. PMID 17398123.

Further reading

• Du X, Poltorak A, Wei Y, Beutler B (2000). "Three novel mammalian toll-like receptors: gene structure, expression, and evolution". Eur. Cytokine Netw. 11 (3): 362–71. PMID 11022119.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Polentarutti N, Rol GP, Muzio M, et al. (2004). "Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR". Eur. Cytokine Netw. 14 (4): 211–8. PMID 14715412.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Qin J, Qian Y, Yao J, et al. (2005). "SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms". J. Biol. Chem. 280 (26): 25233–41. doi:10.1074/jbc.M501363200. PMID 15866876.

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