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SIGIRR
Identifiers
Aliases	SIGIRR, TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, IL-1R8, single Ig and TIR domain containing
External IDs	OMIM: 605478; MGI: 1344402; HomoloGene: 36399; GeneCards: SIGIRR; OMA:SIGIRR - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.5 Start 405,716 bp End 417,455 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F5 Start 140,671,088 bp End 140,680,485 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte mucosa of transverse colon right lobe of liver right uterine tube apex of heart olfactory zone of nasal mucosa spleen body of stomach C1 segment left uterine tube Top expressed in yolk sac right kidney proximal tubule human kidney epithelium of small intestine thymus intestinal villus crypt of lieberkuhn of small intestine ileum submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane membrane plasma membrane Biological process negative regulation of cytokine-mediated signaling pathway acute-phase response negative regulation of DNA-binding transcription factor activity signal transduction negative regulation of lipopolysaccharide-mediated signaling pathway cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 59307 24058 Ensembl ENSG00000185187 ENSMUSG00000025494 UniProt Q6IA17 Q9JLZ8 RefSeq (mRNA) NM_001135053 NM_001135054 NM_021805 NM_023059 NM_001355055 RefSeq (protein) NP_001128525 NP_001128526 NP_068577 NP_075546 NP_001341984 Location (UCSC) Chr 11: 0.41 – 0.42 Mb Chr 7: 140.67 – 140.68 Mb PubMed search
Wikidata
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Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, also known as SIGIRR, is a human gene.

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References

1. ^ GRCh38: Ensembl release 89: ENSG00000185187 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000025494 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain".

Further reading

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