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SIGIRR
Identifiers
Aliases	SIGIRR, TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, IL-1R8, single Ig and TIR domain containing
External IDs	OMIM: 605478; MGI: 1344402; HomoloGene: 36399; GeneCards: SIGIRR; OMA:SIGIRR - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.5 Start 405,716 bp End 417,455 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F5 Start 140,671,088 bp End 140,680,485 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte mucosa of transverse colon right lobe of liver right uterine tube apex of heart olfactory zone of nasal mucosa spleen body of stomach C1 segment left uterine tube Top expressed in yolk sac right kidney proximal tubule human kidney epithelium of small intestine thymus intestinal villus crypt of lieberkuhn of small intestine ileum submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane membrane plasma membrane Biological process negative regulation of cytokine-mediated signaling pathway acute-phase response negative regulation of DNA-binding transcription factor activity signal transduction negative regulation of lipopolysaccharide-mediated signaling pathway cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 59307 24058 Ensembl ENSG00000185187 ENSMUSG00000025494 UniProt Q6IA17 Q9JLZ8 RefSeq (mRNA) NM_001135053 NM_001135054 NM_021805 NM_023059 NM_001355055 RefSeq (protein) NP_001128525 NP_001128526 NP_068577 NP_075546 NP_001341984 Location (UCSC) Chr 11: 0.41 – 0.42 Mb Chr 7: 140.67 – 140.68 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

References

1. ^ GRCh38: Ensembl release 89: ENSG00000185187 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000025494 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Molgora, Martina; Supino, Domenico; Mantovani, Alberto; Garlanda, Cecilia (2018). "Tuning inflammation and immunity by the negative regulators IL-1R2 and IL-1R8". Immunological Reviews. 281 (1): 233–247. doi:10.1111/imr.12609. ISSN 1600-065X. PMC 5922415. PMID 29247989.{{cite journal}}: CS1 maint: PMC format (link)
6. "Sigirr single immunoglobulin and toll-interleukin 1 receptor (TIR) domain [Mus musculus (house mouse)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-01-24.
7. ^ Thomassen, Elisabeth; Renshaw, Blair R.; Sims, John E. (1999-06-01). "Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily". Cytokine. 11 (6): 389–399. doi:10.1006/cyto.1998.0452. ISSN 1043-4666.
8. ^ Zhao, Junjie; Bulek, Katarzyna; Gulen, Muhammet F.; Zepp, Jarod A.; Karagkounis, Georgio; Martin, Bradley N.; Zhou, Hao; Yu, Minjia; Liu, Xiuli; Huang, Emina; Fox, Paul L. (December 2015). "Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice". Gastroenterology. 149 (7): 1860–1871.e8. doi:10.1053/j.gastro.2015.08.051. ISSN 0016-5085. PMC 5308447. PMID 26344057.{{cite journal}}: CS1 maint: PMC format (link)
9. Vilia, Maria Giovanna; Fonte, Eleonora; Veliz Rodriguez, Tania; Tocchetti, Marta; Ranghetti, Pamela; Scarfò, Lydia; Papakonstantinou, Nikos; Ntoufa, Stavroula; Stamatopoulos, Kostas; Ghia, Paolo; Muzio, Marta (2017-10-03). "The inhibitory receptor toll interleukin-1R 8 (TIR8/IL-1R8/SIGIRR) is downregulated in chronic lymphocytic leukemia". Leukemia & Lymphoma. 58 (10): 2419–2425. doi:10.1080/10428194.2017.1295142. ISSN 1042-8194.
10. ^ Kadota, C.; Ishihara, S.; Aziz, M. M.; Rumi, M. A.; Oshima, N.; Mishima, Y.; Moriyama, I.; Yuki, T.; Amano, Y.; Kinoshita, Y. (2010). "Down-regulation of single immunoglobulin interleukin-1R-related molecule (SIGIRR)/TIR8 expression in intestinal epithelial cells during inflammation". Clinical & Experimental Immunology. 162 (2): 348–361. doi:10.1111/j.1365-2249.2010.04254.x. ISSN 1365-2249. PMC 2996602. PMID 21077278.{{cite journal}}: CS1 maint: PMC format (link)
11. Ueno-Shuto, Keiko; Kato, Kosuke; Tasaki, Yukihiro; Sato, Miki; Sato, Keizo; Uchida, Yuji; Sakai, Hiromichi; Ono, Tomomi; Suico, Mary Ann; Mitsutake, Kazunori; Tokutomi, Naofumi (June 2014). "Lipopolysaccharide Decreases Single Immunoglobulin Interleukin-1 Receptor-related Molecule (SIGIRR) Expression by Suppressing Specificity Protein 1 (Sp1) via the Toll-like Receptor 4 (TLR4)-p38 Pathway in Monocytes and Neutrophils". Journal of Biological Chemistry. 289 (26): 18097–18109. doi:10.1074/jbc.m113.532093. ISSN 0021-9258. PMC 4140261. PMID 24821721.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)
12. ^ Qin, Jinzhong; Qian, Youcun; Yao, Jianhong; Grace, Cui; Li, Xiaoxia (2005-05-02). "SIGIRR Inhibits Interleukin-1 Receptor- and Toll-like Receptor 4-mediated Signaling through Different Mechanisms". Journal of Biological Chemistry. 280 (26): 25233–25241. doi:10.1074/jbc.m501363200. ISSN 0021-9258.{{cite journal}}: CS1 maint: unflagged free DOI (link)
13. ^ Wald, David; Qin, Jinzhong; Zhao, Zhendong; Qian, Youcun; Naramura, Mayumi; Tian, Liping; Towne, Jennifer; Sims, John E.; Stark, George R.; Li, Xiaoxia (September 2003). "SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling". Nature Immunology. 4 (9): 920–927. doi:10.1038/ni968. ISSN 1529-2916.
14. ^ Guven-Maiorov, Emine; Keskin, Ozlem; Gursoy, Attila; Nussinov, Ruth (2015-09-15). "A Structural View of Negative Regulation of the Toll-like Receptor-Mediated Inflammatory Pathway". Biophysical Journal. 109 (6): 1214–1226. doi:10.1016/j.bpj.2015.06.048. ISSN 0006-3495. PMC 4576153. PMID 26276688.{{cite journal}}: CS1 maint: PMC format (link)
15. Gong, Jing; Wei, Tiandi; Stark, Robert W.; Jamitzky, Ferdinand; Heckl, Wolfgang M.; Anders, Hans J.; Lech, Maciej; Rössle, Shaila C. (2010-03-01). "Inhibition of Toll-like receptors TLR4 and 7 signaling pathways by SIGIRR: A computational approach". Journal of Structural Biology. 169 (3): 323–330. doi:10.1016/j.jsb.2009.12.007. ISSN 1047-8477.
16. Gulen, Muhammet F.; Kang, Zizhen; Bulek, Katarzyna; Youzhong, Wan; Kim, Tae Whan; Chen, Yi; Altuntas, Cengiz Z.; Sass Bak-Jensen, Kristian; McGeachy, Mandy J.; Do, Jeong-Su; Xiao, Hui (January 2010). "The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation". Immunity. 32 (1): 54–66. doi:10.1016/j.immuni.2009.12.003. ISSN 1074-7613. PMC 3015141. PMID 20060329.{{cite journal}}: CS1 maint: PMC format (link)
17. Xiao, Hui; Yin, Weiguo; Khan, Mohammed A.; Gulen, Muhammet F.; Zhou, Hang; Sham, Ho Pan; Jacobson, Kevan; Vallance, Bruce A.; Li, Xiaoxia (August 2010). "Loss of Single Immunoglobulin Interlukin-1 Receptor-Related Molecule Leads to Enhanced Colonic Polyposis in Apcmin Mice". Gastroenterology. 139 (2): 574–585. doi:10.1053/j.gastro.2010.04.043. PMC 3261756. PMID 20416302.{{cite journal}}: CS1 maint: PMC format (link)
18. Nold-Petry, Claudia A.; Lo, Camden Y.; Rudloff, Ina; Elgass, Kirstin D.; Li, Suzhao; Gantier, Michael P.; Lotz-Havla, Amelie S.; Gersting, Søren W.; Cho, Steven X.; Lao, Jason C.; Ellisdon, Andrew M. (April 2015). "IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction". Nature Immunology. 16 (4): 354–365. doi:10.1038/ni.3103. ISSN 1529-2916.
19. Li, Suzhao; Neff, C. Preston; Barber, Kristina; Hong, Jaewoo; Luo, Yuchun; Azam, Tania; Palmer, Brent E.; Fujita, Mayumi; Garlanda, Cecilia; Mantovani, Alberto; Kim, Soohyun (2015-02-05). "Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8". Proceedings of the National Academy of Sciences. 112 (8): 2497–2502. doi:10.1073/pnas.1424626112. ISSN 0027-8424. PMC 4345608. PMID 25654981.{{cite journal}}: CS1 maint: PMC format (link)
20. Cavalli, Giulio; Justice, Jamie N.; Boyle, Kristen E.; D’Alessandro, Angelo; Eisenmesser, Elan Z.; Herrera, Jonathan J.; Hansen, Kirk C.; Nemkov, Travis; Stienstra, Rinke; Garlanda, Cecilia; Mantovani, Alberto (2017-02-28). "Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance". Proceedings of the National Academy of Sciences. 114 (9): 2313–2318. doi:10.1073/pnas.1619011114. ISSN 0027-8424. PMC 5338542. PMID 28193888.{{cite journal}}: CS1 maint: PMC format (link)

Further reading

• Du X, Poltorak A, Wei Y, Beutler B (2000). "Three novel mammalian toll-like receptors: gene structure, expression, and evolution". Eur. Cytokine Netw. 11 (3): 362–71. PMID 11022119.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Polentarutti N, Rol GP, Muzio M, et al. (2004). "Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR". Eur. Cytokine Netw. 14 (4): 211–8. PMID 14715412.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Qin J, Qian Y, Yao J, et al. (2005). "SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms". J. Biol. Chem. 280 (26): 25233–41. doi:10.1074/jbc.M501363200. PMID 15866876.

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