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CA7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MDZ, 3ML5
Identifiers
Aliases	CA7, CAVII, carbonic anhydrase 7, CA-VII
External IDs	OMIM: 114770; MGI: 103100; HomoloGene: 55875; GeneCards: CA7; OMA:CA7 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.1 Start 66,844,414 bp End 66,854,153 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 D3 Start 105,261,321 bp End 105,276,975 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum mucosa of sigmoid colon testicle Brodmann area 10 right frontal lobe Brodmann area 9 putamen caudate nucleus cingulate gyrus Top expressed in yolk sac Paneth cell trigeminal ganglion facial motor nucleus substantia nigra cerebellar vermis lobe of cerebellum visual cortex Region I of hippocampus proper primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbonate dehydratase activity zinc ion binding metal ion binding lyase activity carbonic anhydrase Cellular component cytoplasm cytosol Biological process bicarbonate transport positive regulation of cellular pH reduction positive regulation of synaptic transmission, GABAergic regulation of chloride transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 766 12354 Ensembl ENSG00000168748 ENSMUSG00000031883 UniProt P43166 Q9ERQ8 RefSeq (mRNA) NM_001014435 NM_005182 NM_001365337 NM_001301164 NM_001301165 NM_053070 RefSeq (protein) NP_001014435 NP_005173 NP_001352266 NP_001288093 NP_001288094 NP_444300 Location (UCSC) Chr 16: 66.84 – 66.85 Mb Chr 8: 105.26 – 105.28 Mb PubMed search
Wikidata
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Carbonic anhydrase 7 (CA7) is an enzyme that in humans is encoded by the CA7 gene.

Function

Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000168748 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000031883 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Montgomery JC, Venta PJ, Eddy RL, Fukushima YS, Shows TB, Tashian RE (Dec 1991). "Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16" (PDF). Genomics. 11 (4): 835–48. doi:10.1016/0888-7543(91)90006-Z. hdl:2027.42/29017. PMID 1783392.
6. ^ "Entrez Gene: CA7 carbonic anhydrase VII".

Further reading

• Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annual Review of Biochemistry. 64: 375–401. doi:10.1146/annurev.bi.64.070195.002111. PMID 7574487.
• Rivera C, Voipio J, Kaila K (Jan 2005). "Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII". The Journal of Physiology. 562 (Pt 1): 27–36. doi:10.1113/jphysiol.2004.077495. PMC 1665491. PMID 15528236.
• Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Sep 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
• Chagnon P, Michaud J, Mitchell G, Mercier J, Marion JF, Drouin E, Rasquin-Weber A, Hudson TJ, Richter A (Dec 2002). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". American Journal of Human Genetics. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
• Vullo D, Voipio J, Innocenti A, Rivera C, Ranki H, Scozzafava A, Kaila K, Supuran CT (Feb 2005). "Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides". Bioorganic & Medicinal Chemistry Letters. 15 (4): 971–6. doi:10.1016/j.bmcl.2004.12.052. PMID 15686895.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Carbonic anhydrase 7

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