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CFHR3
Identifiers
Aliases	CFHR3, CFHL3, DOWN16, FHR-3, FHR3, HLF4, complement factor H related 3
External IDs	OMIM: 605336; HomoloGene: 137347; GeneCards: CFHR3; OMA:CFHR3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q31.3 Start 196,774,813 bp End 196,795,407 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver testicle epithelium of colon left coronary artery right coronary artery popliteal artery tibial arteries tibial nerve Descending thoracic aorta right auricle n/a More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 10878 n/a Ensembl ENSG00000116785 n/a UniProt Q02985 n/a RefSeq (mRNA) NM_001166624 NM_021023 n/a RefSeq (protein) NP_001160096 NP_066303 n/a Location (UCSC) Chr 1: 196.77 – 196.8 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Complement factor H-related protein 3 is a protein that in humans is encoded by the CFHR3 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000116785 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Skerka C, Kuhn S, Gunther K, Lingelbach K, Zipfel PF (Mar 1993). "A novel short consensus repeat-containing molecule is related to human complement factor H". J Biol Chem. 268 (4): 2904–8. doi:10.1016/S0021-9258(18)53859-X. PMID 8428964.
4. Diaz-Guillen MA, Rodriguez de Cordoba S, Heine-Suner D (Jul 1999). "A radiation hybrid map of complement factor H and factor H-related genes". Immunogenetics. 49 (6): 549–52. doi:10.1007/s002510050534. PMID 10380701. S2CID 31776506.
5. "Entrez Gene: CFHR3 complement factor H-related 3".

Further reading

• Zipfel PF, Skerka C (1994). "Complement factor H and related proteins: an expanding family of complement-regulatory proteins?". Immunol. Today. 15 (3): 121–6. doi:10.1016/0167-5699(94)90155-4. PMID 8172644.
• Hellwage J, Jokiranta TS, Koistinen V, et al. (2000). "Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin". FEBS Lett. 462 (3): 345–52. doi:10.1016/S0014-5793(99)01554-9. PMID 10622723. S2CID 41308410.
• Male DA, Ormsby RJ, Ranganathan S, et al. (2000). "Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes". Mol. Immunol. 37 (1–2): 41–52. doi:10.1016/S0161-5890(00)00024-9. PMID 10781834.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Zipfel PF, Edey M, Heinen S, et al. (2007). "Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome". PLOS Genet. 3 (3): e41. doi:10.1371/journal.pgen.0030041. PMC 1828695. PMID 17367211.

External links

• GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
• OMIM entries on Atypical Hemolytic-Uremic Syndrome
• Human CFHR3 genome location and CFHR3 gene details page in the UCSC Genome Browser.

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