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CUL1

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Protein-coding gene in humans
CUL1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1LDJ, 1LDK, 1U6G, 3RTR, 3TDU, 3TDZ, 4F52, 4P5O

Identifiers
AliasesCUL1, cullin 1
External IDsOMIM: 603134; MGI: 1349658; HomoloGene: 2663; GeneCards: CUL1; OMA:CUL1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)
Chromosome 7 (human)Genomic location for CUL1Genomic location for CUL1
Band7q36.1Start148,697,914 bp
End148,801,110 bp
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)
Chromosome 6 (mouse)Genomic location for CUL1Genomic location for CUL1
Band6|6 B2.3Start47,430,332 bp
End47,503,073 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • left testis

  • right testis

  • ganglionic eminence

  • sperm

  • gastrocnemius muscle

  • Achilles tendon

  • biceps brachii

  • ventricular zone

  • Skeletal muscle tissue of biceps brachii
Top expressed in
  • secondary oocyte

  • zygote

  • tail of embryo

  • genital tubercle

  • primary oocyte

  • ventricular zone

  • medullary collecting duct

  • spermatocyte

  • renal corpuscle

  • neural layer of retina
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8454

26965

Ensembl

ENSG00000055130

ENSMUSG00000029686

UniProt

Q13616

Q9WTX6

RefSeq (mRNA)

NM_003592

NM_012042
NM_001355550
NM_001355551

RefSeq (protein)

NP_003583

NP_036172
NP_001342479
NP_001342480

Location (UCSC)Chr 7: 148.7 – 148.8 MbChr 6: 47.43 – 47.5 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination.

This is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, it serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.

This protein is a part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. It also interacts with RNF7. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with TIP120A/CAND1 and the interaction negatively regulates the association with SKP1 in the SCF complex. Interacts with COPS2.

It is expressed in lung fibroblasts.

The protein is neddylated, which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.

Further reading

PDB gallery
  • 1ldj: Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex 1ldj: Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex
  • 1ldk: Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex 1ldk: Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex
  • 1u6g: Crystal Structure of The Cand1-Cul1-Roc1 Complex 1u6g: Crystal Structure of The Cand1-Cul1-Roc1 Complex

External links

Stub icon

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  1. ^ GRCh38: Ensembl release 89: ENSG00000055130Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000029686Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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