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CYTIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Z17
Identifiers
Aliases	CYTIP, B3-1, CASP, CYBR, CYTHIP, HE, PSCDBP, cytohesin 1 interacting protein
External IDs	OMIM: 604448; MGI: 2183535; HomoloGene: 3167; GeneCards: CYTIP; OMA:CYTIP - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q24.1 Start 157,414,619 bp End 157,488,961 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 C1.1 Start 58,019,149 bp End 58,085,544 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood bone marrow cells white blood cell monocyte appendix lymph node granulocyte epithelium of colon epithelium of nasopharynx spleen Top expressed in granulocyte spleen mesenteric lymph nodes right lung lobe thymus blood tibiofemoral joint lactiferous gland bone marrow Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm endosome cell cortex early endosome nucleoplasm cytosol Biological process regulation of cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9595 227929 Ensembl ENSG00000115165 ENSMUSG00000026832 UniProt O60759 Q91VY6 RefSeq (mRNA) NM_004288 NM_139200 RefSeq (protein) NP_004279 NP_631939 Location (UCSC) Chr 2: 157.41 – 157.49 Mb Chr 2: 58.02 – 58.09 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Cytohesin-interacting protein is a protein that in humans is encoded by the CYTIP gene.

The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, and it does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000115165 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000026832 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dixon B, Sahely B, Liu L, Pohajdak B (Jan 1994). "Cloning a cDNA from human NK/T cells which codes for an unusual leucine zipper containing protein". Biochim Biophys Acta. 1216 (2): 321–4. doi:10.1016/0167-4781(93)90165-a. PMID 8241278.
6. Kim HS (Jun 1999). "Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11.2 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (1–2): 95. doi:10.1159/000015226. PMID 10343115. S2CID 7420858.
7. Tang P, Cheng TP, Agnello D, Wu CY, Hissong BD, Watford WT, Ahn HJ, Galon J, Moss J, Vaughan M, O'Shea JJ, Gadina M (Mar 2002). "Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity". Proc Natl Acad Sci USA. 99 (5): 2625–9. Bibcode:2002PNAS...99.2625T. doi:10.1073/pnas.052712999. PMC 122398. PMID 11867758.
8. ^ "Entrez Gene: PSCDBP pleckstrin homology, Sec7 and coiled-coil domains, binding protein".

Further reading

• Mansour M, Lee SY, Pohajdak B (2002). "The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP". J. Biol. Chem. 277 (35): 32302–9. doi:10.1074/jbc.M202898200. PMID 12052827.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Boehm T, Hofer S, Winklehner P, et al. (2003). "Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration". EMBO J. 22 (5): 1014–24. doi:10.1093/emboj/cdg101. PMC 150334. PMID 12606567.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Chen Q, Coffey A, Bourgoin SG, Gadina M (2006). "Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathway". J. Biol. Chem. 281 (29): 19985–94. doi:10.1074/jbc.M601629200. PMID 16702224.
• MacNeil AJ, Mansour M, Pohajdak B (2007). "Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes". Biochem. Biophys. Res. Commun. 359 (4): 848–53. doi:10.1016/j.bbrc.2007.05.162. PMID 17577583.

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