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As of the 2020 redistricting, California's 52nd congressional district is located in Southern California. It encompasses the South Bay region of San Diego County.
San Diego County is split between this district, the 50th district, the 51st district, and the 48th district. The 52nd and 48th are partitioned by San Miguel Rd, Proctor Valley Rd, Camino Mojave/Jonel Way, Highway 125, Upper Otay Reservoir, Otay Lakes Rd, Otay Valley Regional Park, Alta Rd, and Otay Mountain Truck Trail.
The 52nd and 50th are partitioned by Iowa St, University Ave, Inland Freeway, Escondido Freeway, Martin Luther King Jr Freeway, John J Montgomery Freeway, and San Diego Bay.
The 52nd and the 51st are partitioned by El Cajon Blvd, 58th St, Streamview Dr, College Ave, Meridian Ave, Lemarand Ave, Highway 94, Charlene Ave, 69th St, Imperial Ave, Larwood Rd, Taft St, Lincoln Pl, Glencoe Dr, Braddock St, Carlisle Dr, Carlsbad Ct/Osage Dr, Potrero St, Carlsbad St, Innsdale Ave, Worthington St/Innsdale Ln, Brady Ct/Innsdale Ln, Parkbrook Way/Alene St, Tinaja Ln/Bluffview Rd, Highway 54, Sweetwater Rd, and Bonita Rd.