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Cementoblastoma

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Benign tumor of the teeth roots Medical condition
Cementoblastoma
Cone beam CT images showing a well-defined hyperdense round lesion attached to the root of supernumerary mandibular tooth (arrow head) with a surrounding hypodense rim.
SpecialtyDentistry


Cementoblastoma, or benign cementoblastoma, is a relatively rare benign neoplasm of the cementum of the teeth. It is derived from ectomesenchyme of odontogenic origin, with the formation of cementum-like tissue around the associated tooth root. Cementoblastomas represent less than 0.69–8% of all odontogenic tumors.The oldest case of cementoblastoma that has been verified dates back to 1888 by J. Metnitz. He described a lesion as a hard rounded mass associated with root resorption, periosteum coverage, rows of bone cells, and pulp chamber involvement. At the time, the lesion was diagnosed as an "odontoma", but later it was found that a diagnosis of cementoblastoma better matched the description.

Diagnostic Features

Clinical

Cementoblastoma usually occurs in people between the ages of 20 to 30, equally affecting males and females. It is more commonly found in the mandible compared to the maxilla (3.4:1), with 40% of cases being found in the first mandibular molar area and incisor involvement being extremely rare. Cementoblastoma rarely affects primary dentition. The latest case reports suggest that only 21 cases of cementoblastoma involving primary teeth have been found in the English literature, 66% of which occurring on the right side.

Radiographic

Cementoblastoma is slow growing well-defined, radiopaque mass, with a radiolucent peripheral line, that overlies and obliterates the tooth root typically presenting with root resorption. It has a rounded or sunburst appearance. Differential diagnosis include severe hypercementosis, chronic focal sclerosing osteomyelitis, and osteoma.

Histologic

Cementoblastoma can be characterized by a fibrous stroma containing a dense collection of acellular material that is cementum-like with basophilic reversal lines.

Molecular

Due to advances in genome sequencing, molecular signatures of odontogenic cysts and tumors are being investigated to aid in differential diagnosis. Rearrangement of the FOS gene and overexpression of c-FOS have been identified in cementoblastoma, similar to osteoblastoma suggesting a link in the disease process of these two tumors.

Treatment

Surgical enucleation of the lesion is done, and depending upon the clinical circumstances, this involve removal of the involved tooth. Recurrence rate ranges from as high as 37.1% to 11.8% with bone expansion and the perforation of the cortical bone predicting greater recurrence.

See also

References

  1. Silva, Brunno Santos Freitas; Bueno, Mike Reis; Yamamoto-Silva, Fernanda P.; Gomez, Ricardo Santiago; Peters, Ove Andreas; Estrela, Carlos (2017-07-03). "Differential diagnosis and clinical management of periapical radiopaque/hyperdense jaw lesions". Brazilian Oral Research. 31: e52. doi:10.1590/1807-3107BOR-2017.vol31.0052. PMID 28678971.
  2. ^ Sankari Leena S, Ramakrishnan K (2011). "Benign cementoblastoma". Journal of Oral and Maxillofacial Pathology. 15 (3): 358–360. doi:10.4103/0973-029X.86725. PMC 3227271. PMID 22144847.
  3. Ide F, Sakamoto S, Miyazaki Y, Hoshino M, Nishimura M, Muramatsu T, Kikuchi K. The True History of Cementoblastoma. Head Neck Pathol. 2023 Jun;17(2):528-533. doi: 10.1007/s12105-022-01499-6. Epub 2023 Feb 1. PMID: 36723849; PMCID: PMC10293505.
  4. ^ Chrcanovic, Bruno Ramos; Gomez, Ricardo Santiago (October 2017). "Cementoblastoma: An updated analysis of 258 cases reported in the literature". Journal of Cranio-Maxillofacial Surgery. 45 (10): 1759–1766. doi:10.1016/j.jcms.2017.08.002. hdl:2043/23314. ISSN 1010-5182. PMID 28869132.
  5. Suhasini, GoturPalakshappa; Wadhwan, Vijay; Garg, Nitin (2020). "Cementoblastoma of a primary molar: A rare pediatric occurrence". Journal of Oral and Maxillofacial Pathology. 24 (3): 548–553. doi:10.4103/jomfp.jomfp_307_19. ISSN 0973-029X. PMC 8083404. PMID 33967495.
  6. ^ Taghsimi, Kimya; Vasilyev, Andrey Vyacheslavovich; Kuznetsova, Valeriya Sergeevna; Galtsova, Angelina Vladimirovna; Badalyan, Varditer Agabekovna; Babichenko, Igor Ivanovich (2022-06-10). "Efficiency and Safety of Dental Implantation in the Area of Hyperdense Jaw Lesions: A Narrative Review". Dentistry Journal. 10 (6): 107. doi:10.3390/dj10060107. ISSN 2304-6767. PMC 9222039. PMID 35735649.

External links

ClassificationD
Dental tumors
Cementoblast
Ameloblast
Mixed/hamartoma
Other
Category: