Charles Mackenzie may refer to:
- Charles Mackenzie (diplomat) (1788–1862), Scottish diplomat, writer and journalist
- Charles Mackenzie (bishop) (1825–1862), Church of England bishop of Central Africa
- Charles MacKenzie (merchant) (1832–1900), Ontario merchant and politician
- Charles Patrick Mackenzie (1924–1986), lecturer in veterinary medicine
- Charles Mackenzie (Australian politician) (1837–1921), member of the Tasmanian House of Assembly
- Charles Mackenzie, 19th-century English actor who performed as Henry Compton
- Sgt. Charles Stuart MacKenzie, World War I Scottish soldier, subject of the lament -- "Sgt. MacKenzie" -- written and sung by his great-grandson Joseph Kilna Mackenzie
See also
- Charles E. McKenzie (1896–1956), U.S. Representative from Louisiana
- Charles McKenzie (born 1974) - Australian activist, raising awareness of the infected blood scandal in Australia
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