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Collagen-induced arthritis (CIA) is a condition induced in mice (or rats) to study rheumatoid arthritis.

CIA is induced in mice by injecting them with an emulsion of complete Freund's adjuvant and type II collagen.

In rats, only one injection is needed, but mice are normally injected twice.

References

1. Williams, RO (2004). "Collagen-induced arthritis as a model for rheumatoid arthritis". Tumor Necrosis Factor. Vol. 98. pp. 207–16. doi:10.1385/1-59259-771-8:207. ISBN 978-1-59259-771-0. PMID 15064442. {{cite book}}: |journal= ignored (help)
2. Brand, DD; Latham, KA; Rosloniec, EF (2007). "Collagen-induced arthritis". Nat Protoc. 2 (5): 1269–75. doi:10.1038/nprot.2007.173. PMID 17546023.
3. Arthritis in mice induced by a single immunisation with collagen

Further reading

• Inglis, Julia J.; Criado, Gabriel; Medghalchi, Mino; Andrews, Melanie; Sandison, Ann; Feldmann, Marc; Williams, Richard O. (29 October 2007). "Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen". Arthritis Research & Therapy. 9 (5): R113. doi:10.1186/ar2319. ISSN 1478-6354. PMC 2212575. PMID 17967186.
• Pietrosimone, K. M.; Jin, M.; Poston, B.; Liu, P. (20 October 2015). "Collagen-Induced Arthritis: A model for Murine Autoimmune Arthritis". Bio-Protocol. 5 (20): e1626. doi:10.21769/bioprotoc.1626. ISSN 2331-8325. PMC 4629450. PMID 26539560.
• Holmdahl, Rikard; Bockermann, Robert; Bäcklund, Johan; Yamada, Hisakata (1 February 2002). "The molecular pathogenesis of collagen-induced arthritis in mice—a model for rheumatoid arthritis". Ageing Research Reviews. 1 (1): 135–147. doi:10.1016/S0047-6374(01)00371-2. ISSN 1568-1637. PMID 12039453. S2CID 28243127.

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