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DCTN5

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Protein-coding gene in the species Homo sapiens

DCTN5
Identifiers
AliasesDCTN5, dynactin subunit 5
External IDsOMIM: 612962; MGI: 1891689; HomoloGene: 10998; GeneCards: DCTN5; OMA:DCTN5 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)
Chromosome 16 (human)Genomic location for DCTN5Genomic location for DCTN5
Band16p12.2Start23,641,466 bp
End23,677,472 bp
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)
Chromosome 7 (mouse)Genomic location for DCTN5Genomic location for DCTN5
Band7|7 F2Start121,732,264 bp
End121,748,267 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • rectum

  • stromal cell of endometrium

  • smooth muscle tissue

  • monocyte

  • mucosa of esophagus

  • ganglionic eminence

  • lymph node

  • epithelium of colon

  • mucosa of transverse colon
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • right kidney

  • granulocyte

  • superior frontal gyrus

  • medial ganglionic eminence

  • yolk sac

  • Pituitary Gland

  • tail of embryo

  • cumulus cell

  • blood
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84516

59288

Ensembl

ENSG00000166847

ENSMUSG00000030868

UniProt

Q9BTE1

Q9QZB9

RefSeq (mRNA)

NM_001199011
NM_001199743
NM_032486

NM_021608

RefSeq (protein)

NP_001185940
NP_001186672
NP_115875

NP_067621

Location (UCSC)Chr 16: 23.64 – 23.68 MbChr 7: 121.73 – 121.75 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Dynactin 5 (p25) is a protein that in humans is encoded by the DCTN5 gene.

This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000166847 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030868 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Dynactin 5 (p25)". Retrieved 2011-09-20.

Further reading

Eckley DM, Gill SR, Melkonian KA, Bingham JB, Goodson HV, Heuser JE, et al. (October 1999). "Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end". The Journal of Cell Biology. 147 (2): 307–320. doi:10.1083/jcb.147.2.307. PMC 2174220. PMID 10525537. Parisi G, Fornasari MS, Echave J (March 2004). "Dynactins p25 and p27 are predicted to adopt the LbetaH fold". FEBS Letters. 562 (1–3): 1–4. doi:10.1016/S0014-5793(04)00165-6. PMID 15043994. S2CID 84381211. Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, et al. (June 2007). "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls". Nature. 447 (7145): 661–678. Bibcode:2007Natur.447..661B. doi:10.1038/nature05911. PMC 2719288. PMID 17554300.

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