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DIP2B

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Protein-coding gene in the species Homo sapiens

DIP2B
Identifiers
AliasesDIP2B, disco interacting protein 2 homolog B
External IDsOMIM: 611379; MGI: 2145977; HomoloGene: 72227; GeneCards: DIP2B; OMA:DIP2B - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)
Chromosome 12 (human)Genomic location for DIP2BGenomic location for DIP2B
Band12q13.12Start50,504,985 bp
End50,748,657 bp
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)
Chromosome 15 (mouse)Genomic location for DIP2BGenomic location for DIP2B
Band15|15 F1Start99,936,545 bp
End100,117,354 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • inferior ganglion of vagus nerve

  • cerebellar vermis

  • subthalamic nucleus

  • corpus callosum

  • Medulla Oblongata

  • superior vestibular nucleus

  • skin of arm

  • pars reticulata

  • Pons

  • external globus pallidus
Top expressed in
  • vestibular membrane of cochlear duct

  • primary oocyte

  • secondary oocyte

  • blood

  • perirhinal cortex

  • sciatic nerve

  • conjunctival fornix

  • spermatid

  • entorhinal cortex

  • cingulate gyrus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57609

239667

Ensembl

ENSG00000066084

ENSMUSG00000023026

UniProt

Q9P265

Q3UH60

RefSeq (mRNA)

NM_020849
NM_173602

NM_001159361
NM_172819

RefSeq (protein)

NP_775873

NP_001152833
NP_766407
NP_001389830

Location (UCSC)Chr 12: 50.5 – 50.75 MbChr 15: 99.94 – 100.12 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

DIP2 disco-interacting protein 2 homolog B (Drosophila) is a protein that in humans is encoded by the DIP2B gene. A member of the disco-interacting protein homolog 2 protein family, it contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1, as well as AMP-binding sites. The presence of these sites suggests that DIP2B may participate in DNA methylation. This gene is located near a folate-sensitive fragile site.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000066084 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000023026 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "DIP2 disco-interacting protein 2 homolog B (Drosophila)". Retrieved 2011-12-05.
  6. Winnepenninckx B, Debacker K, Ramsay J, Smeets D, Smits A, FitzPatrick DR, et al. (February 2007). "CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1". American Journal of Human Genetics. 80 (2): 221–231. doi:10.1086/510800. PMC 1785358. PMID 17236128.

Further reading

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