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Fominoben

Clinical data
Trade names	Broncomenal, Deronyl, Finaten, Noleptan, Oleptan, Terion, Tosifar, Tussirama
Identifiers
IUPAC name N-methyl]phenyl]benzamide
CAS Number	18053-31-1
PubChem CID	3407
DrugBank	DB08968
ChemSpider	3290
UNII	TJ2KK6NYJS
KEGG	D07988
ChEBI	CHEBI:135639
ChEMBL	ChEMBL1697837
CompTox Dashboard (EPA)	DTXSID1023075
ECHA InfoCard	100.038.135
Chemical and physical data
Formula	C21H24ClN3O3
Molar mass	401.89 g·mol
3D model (JSmol)	Interactive image
SMILES CN(CC1=C(C=CC=C1Cl)NC(=O)C2=CC=CC=C2)CC(=O)N3CCOCC3
InChI InChI=1S/C21H24ClN3O3/c1-24(15-20(26)25-10-12-28-13-11-25)14-17-18(22)8-5-9-19(17)23-21(27)16-6-3-2-4-7-16/h2-9H,10-15H2,1H3,(H,23,27) Key:KSNNEUZOAFRTDS-UHFFFAOYSA-N

Fominoben is an antitussive agent of the benzanilide class, formerly marketed under the name Noleptan. It binds poorly to the sigma-1 receptor, a receptor activated by many other antitussives. It is reported to have respiratory stimulant activity. Other research has indicated it may be an agonist at the benzodiazepine site of the GABA_A receptor. It was introduced in Germany in 1973, in Italy in 1979, and in Japan in 1983.

Adverse effects include appetite suppression, nausea, vomiting, insomnia, irritability, and hallucinations. Rarer side effects include somnolence, dizziness, dry mouth, blurred vision, and urticaria.

References

1. Swiss Pharmaceutial Society, ed. (January 2000). Index Nominum 2000: International Drug Directory. Taylor & Francis. p. 470. ISBN 978-3-88763-075-1.
2. "FOMINOBEN". NCATS Inxight: Drugs. Retrieved March 25, 2021.
3. Musacchio JM, Klein M (June 1988). "Dextromethorphan binding sites in the guinea pig brain". Cellular and Molecular Neurobiology. 8 (2): 149–56. doi:10.1007/BF00711241. PMID 3044591. S2CID 33844132.
4. Sasaki T, Sugiyama M, Sasaki H, Suzuki S, Takishima T (1985). "Effects of the antitussive fominoben (PB89) on hypoxia in chronic obstructive lung disease: comparison with dextromethorphan using a double-blind method". The Journal of International Medical Research. 13 (2): 96–101. doi:10.1177/030006058501300204. PMID 3158563. S2CID 30176251.
5. Crawley JN, Blumstein LK, Baldino F (January 1984). "Anxiolytic-like properties of fominoben". European Journal of Pharmacology. 97 (3–4): 277–81. doi:10.1016/0014-2999(84)90460-6. PMID 6142823.
6. William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia. Elsevier. pp. 1705–7. ISBN 978-0-8155-1856-3.
7. Martín AV (2004). "Tratamiento sintomático de la tos y del resfriado común". Farmacología clínica y terapéutica médica. McGraw-Hill/Interamericana. p. 260. ISBN 9788448604271.

• Antitussives
• GABAA receptor positive allosteric modulators
• Benzanilides
• 4-Morpholinyl compounds
• Chloroarenes
• Tertiary amines