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Fructuronate reductase

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fructuronate reductase
Identifiers
EC no.1.1.1.57
CAS no.9028-44-8
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In enzymology, a fructuronate reductase (EC 1.1.1.57) is an enzyme that catalyzes the chemical reaction

D-mannonate + NAD {\displaystyle \rightleftharpoons } D-fructuronate + NADH + H

Thus, the two substrates of this enzyme are D-mannonate and NAD, whereas its 3 products are D-fructuronate, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is D-mannonate:NAD 5-oxidoreductase. Other names in common use include mannonate oxidoreductase, mannonic dehydrogenase, D-mannonate dehydrogenase, and D-mannonate:NAD oxidoreductase. This enzyme participates in pentose and glucuronate interconversions.

References

  • Hickman J; Ashwell G (1960). "Uronic acid metabolism in bacteria. II. Purification and properties of D-altronic acid and D-mannonic acid dehyrogenases in Escherichia coli". J. Biol. Chem. 235: 1566–1570.
  • Kilgore WW, Starr MP (1959). "Catabolism of galacturonic and glucuronic acids by Erwinia carotovora". J. Biol. Chem. 234: 2227–35. PMID 14409051.
Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
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