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Glomeruloid hemangioma is a distinctive vascular tumor first described in 1990 when found to be associated with POEMS syndrome and Castleman disease. Glomeruloid hemangiomas can manifest as wine-red sessile or pedunculated papules, papulonodules, subcutaneous bluish compressible tumors, or small, firm, reddish-violaceous, dome-shaped papules.

Signs and symptoms

Glomeruloid hemangiomas can manifest as wine-red sessile or pedunculated papules, papulonodules, subcutaneous bluish compressible tumors, or small, firm, reddish-violaceous, dome-shaped papules. They mostly reside on the trunk and proximal limbs and range in size from a few millimeters to a few centimeters in diameter. There have also been rare reports of glomeruloid hemangioma impacting the face. There have also been reports of eruptive angiomatous lesions, which resemble eruptive histiocytomas.

Causes

Glomeruloid hemangiomas are most commonly associated with POEMS syndrome, occurring in up to 45% of individuals with POEMS syndrome. Glomeruloid hemangiomas have also been associated with TAFRO syndrome. Rarely glomeruloid hemangiomas can occur in individuals with no systematic conditions.

Diagnosis

The histopathologic examination displays well-defined, dispersed dermal structures in different sizes that have resemblance to renal glomeruli. The central vessel is bigger and has a sinusoidal appearance, and it is surrounded by a network of small capillary vessels on the periphery.

See also

• POEMS syndrome
• Hemangioma

References

1. James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "28. Dermal and subcutaneous tumors". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 594. ISBN 978-0-323-54753-6.
2. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
3. Gupta, Jyoti; Kandhari, Rajat; Ramesh, V; Singh, Avninder (2013). "Glomeruloid hemangioma in normal individuals". Indian Journal of Dermatology. 58 (2). Medknow: 160. doi:10.4103/0019-5154.108088. ISSN 0019-5154. PMC 3657245. PMID 23716835.
4. Puig, Lluis; Moreno, Abelardo; Domingo, Pere; Llistosella, Enric; de Moragas, José M. (1985). "Cutaneous angiomas in POEMS syndrome". Journal of the American Academy of Dermatology. 12 (5). Elsevier BV: 961–964. doi:10.1016/s0190-9622(85)70123-5. ISSN 0190-9622. PMID 3158680.
5. Chan, P. T.; Lee, K. C.; Chong, L. Y.; Lo, K. K.; Cheung, Y. F. (2006). "Glomeruloid haemangioma with cerebriform morphology in a patient with POEMS syndrome". Clinical and Experimental Dermatology. 31 (6). Oxford University Press (OUP): 775–777. doi:10.1111/j.1365-2230.2006.02213.x. ISSN 0307-6938. PMID 17040261.
6. Tsai, Chang-Yu; Lai, Chan-Ho; Chan, Heng-Leong; Kuo, Tseng-tong (2001). "Glomeruloid hemangioma –- a specific cutaneous marker of POEMS syndrome". International Journal of Dermatology. 40 (6). Wiley: 403–406. doi:10.1046/j.1365-4362.2001.01246-2.x. ISSN 0011-9059. PMID 11589746.
7. Yang, Seong Gyu; Cho, Kwang Hyun; Bang, Yung-Jue; Kim, Chul Woo (1998). "A Case of Glomeruloid Hemangioma Associated With Multicentric Castleman's Disease". The American Journal of Dermatopathology. 20 (3). Ovid Technologies (Wolters Kluwer Health): 266–270. doi:10.1097/00000372-199806000-00008. ISSN 0193-1091. PMID 9650700.
8. Perniciaro, Charles (1995). "POEMS syndrome". Seminars in Dermatology. 14 (2). Elsevier BV: 162–165. doi:10.1016/s1085-5629(05)80013-6. ISSN 0278-145X. PMID 7640197.
9. Mocellin, Simone (2021). "Glomeruloid Hemangioma". Soft Tissue Tumors. Cham: Springer International Publishing. pp. 377–378. doi:10.1007/978-3-030-58710-9_112. ISBN 978-3-030-58709-3.
10. Shinozaki-Ushiku, Aya; Higashihara, Takaaki; Ikemura, Masako; Sato, Junichiro; Nangaku, Masaomi; Ushiku, Tetsuo; Fukayama, Masashi (2018). "Glomeruloid hemangioma associated with TAFRO syndrome". Human Pathology. 82. Elsevier BV: 172–176. doi:10.1016/j.humpath.2018.04.011. ISSN 0046-8177. PMID 29702119.
11. Roy, Rita R; Shimada, Katsumitsu; Hasegawa, Hiromasa (2022-01-29). "A Case of Oral Glomeruloid Hemangioma Without Systemic Conditions". Cureus. 14 (1): e21705. doi:10.7759/cureus.21705. ISSN 2168-8184. PMC 8803383. PMID 35145824.
12. Hernández Aragüés, I.; Pulido Pérez, A.; Ciudad Blanco, C.; Parra Blanco, V.; Suárez Fernández, R. (2017). "Glomeruloid Hemangioma and POEMS Syndrome". Actas Dermo-Sifiliográficas (English Edition). 108 (2). Elsevier BV: e15 – e19. doi:10.1016/j.adengl.2016.12.006. ISSN 1578-2190.

Further reading

• González-Guerra, E.; Haro, M. R.; Fariña, M. C.; Martín, L.; Manzarbeitia, L.; Requena, L. (2009). "Glomeruloid haemangioma is not always associated with POEMS syndrome". Clinical and Experimental Dermatology. 34 (7). Oxford University Press (OUP): 800–803. doi:10.1111/j.1365-2230.2008.02997.x. ISSN 0307-6938. PMID 19077091.
• Phillips, Julie A.; Dixon, Julie E.; Richardson, Jeffrey B.; Fabre, Vilma C.; Callen, Jeffrey P. (2006). "Glomeruloid hemangioma leading to a diagnosis of POEMS syndrome". Journal of the American Academy of Dermatology. 55 (1). Elsevier BV: 149–152. doi:10.1016/j.jaad.2006.02.036. ISSN 0190-9622. PMID 16781311.

External links

• DermNet
• VisualDx

• Dermal and subcutaneous growths