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H1-3
Identifiers
Aliases	H1-3, H1.3, H1D, H1F3, H1s-2, histone cluster 1, H1d, histone cluster 1 H1 family member d, H1.3 linker histone, cluster member, HIST1H1D
External IDs	OMIM: 142210; MGI: 107502; HomoloGene: 68456; GeneCards: H1-3; OMA:H1-3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.2 Start 26,234,212 bp End 26,234,987 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A3.1 Start 23,737,436 bp End 23,744,860 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gonad epithelium of colon bone marrow cells testicle ventricular zone tonsil embryo sural nerve ganglionic eminence Top expressed in gray matter layer of cerebellum seminiferous tubule hair follicle mandibular prominence primitive streak abdominal wall ascending aorta aortic valve fossa endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding chromatin DNA binding RNA binding double-stranded DNA binding protein binding nucleosomal DNA binding Cellular component nucleosome nucleus chromosome Biological process regulation of transcription by RNA polymerase II histone H3-K4 trimethylation nucleosome assembly negative regulation of transcription by RNA polymerase II histone H3-K27 trimethylation regulation of transcription, DNA-templated chromosome condensation negative regulation of DNA recombination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3007 14957 Ensembl ENSG00000124575 ENSMUSG00000052565 UniProt P16402 P43277 RefSeq (mRNA) NM_005320 NM_145713 RefSeq (protein) NP_005311 NP_663759 Location (UCSC) Chr 6: 26.23 – 26.23 Mb Chr 13: 23.74 – 23.74 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Histone H1.3 is a protein that in humans is encoded by the HIST1H1D gene.

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000124575 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000052565 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825.
6. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
7. ^ "Entrez Gene: HIST1H1D histone cluster 1, H1d".

Further reading

• Allen BS, Stein JL, Stein GS, Ostrer H (1991). "Single-copy flanking sequences in human histone gene clusters map to chromosomes 1 and 6". Genomics. 10 (2): 486–8. doi:10.1016/0888-7543(91)90337-E. PMID 2071153.
• Ohe Y, Hayashi H, Iwai K (1990). "Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d". J. Biochem. 106 (5): 844–57. doi:10.1093/oxfordjournals.jbchem.a122941. PMID 2613692.
• Albig W, Drabent B, Kunz J, et al. (1993). "All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6". Genomics. 16 (3): 649–54. doi:10.1006/geno.1993.1243. PMID 8325638.
• Albig W, Kioschis P, Poustka A, et al. (1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
• Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
• Olins AL, Herrmann H, Lichter P, et al. (2001). "Nuclear envelope and chromatin compositional differences comparing undifferentiated and retinoic acid- and phorbol ester-treated HL-60 cells". Exp. Cell Res. 268 (2): 115–27. doi:10.1006/excr.2001.5269. PMID 11478838.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Garcia BA, Busby SA, Barber CM, et al. (2005). "Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry". J. Proteome Res. 3 (6): 1219–27. doi:10.1021/pr0498887. PMID 15595731.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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