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HIST1H2AM

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(Redirected from H2AC17) Protein-coding gene in the species Homo sapiens
H2AC17
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4QYL, 5KGF

Identifiers
AliasesH2AC17, H2A.1, H2A/n, H2AFN, dJ193B12.1, histone cluster 1, H2am, histone cluster 1 H2A family member m, H2A clustered histone 17, HIST1H2AM, H2AC11, H2AC15, H2AC16, H2AC13
External IDsOMIM: 602796; MGI: 2448289; HomoloGene: 136769; GeneCards: H2AC17; OMA:H2AC17 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)
Chromosome 6 (human)Genomic location for H2AC17Genomic location for H2AC17
Band6p22.1Start27,892,699 bp
End27,893,185 bp
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)
Chromosome 13 (mouse)Genomic location for H2AC17Genomic location for H2AC17
Band13|13 A3.1Start23,758,555 bp
End23,759,126 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bone marrow cells

  • gonad

  • testicle

  • Achilles tendon

  • monocyte

  • corpus callosum

  • tonsil

  • mucosa of transverse colon

  • blood

  • granulocyte
Top expressed in
  • embryo

  • embryo

  • uterus

  • Mesencephalon

  • neural tube

  • spermatid

  • morula

  • bone marrow

  • spermatocyte

  • tail of embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8336

319165

Ensembl

ENSG00000278677

ENSMUSG00000071478

UniProt

P0C0S8

C0HKE2
B2RVF0
C0HKE1
C0HKE3
C0HKE5

C0HKE4
C0HKE6
C0HKE7
C0HKE8
C0HKE9

RefSeq (mRNA)

NM_003514

NM_178188

RefSeq (protein)

NP_066408
NP_003505

NP_835496
NP_835495
NP_835494
NP_835491
NP_835489

NP_783591
NP_835493
NP_835496
NP_835489
NP_835495
NP_835494
NP_835491
NP_835492
NP_783591
NP_001171015
NP_835489
NP_001171015
NP_835496
NP_835491
NP_835493
NP_835494
NP_835495
NP_835492
NP_783591
NP_835495
NP_835489
NP_835494
NP_835491
NP_835492
NP_783591
NP_001171015
NP_835493
NP_835496
NP_835494
NP_835489
NP_835495
NP_835491
NP_835492
NP_783591
NP_001171015
NP_835493
NP_835496
NP_835492
NP_835491
NP_835489
NP_835495
NP_835494
NP_783591
NP_001171015
NP_835493
NP_835496
NP_835491
NP_835489
NP_835495
NP_835494
NP_835492
NP_783591
NP_001171015
NP_835493
NP_835496
NP_783591
NP_835489
NP_835495
NP_835494
NP_835491
NP_835492
NP_001171015
NP_835493
NP_835496
NP_783591
NP_835489
NP_835495
NP_835494
NP_835491
NP_835492
NP_001171015
NP_835493
NP_835496

Location (UCSC)Chr 6: 27.89 – 27.89 MbChr 13: 23.76 – 23.76 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AM gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000278677Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000071478Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dobner T, Wolf I, Mai B, Lipp M (Feb 1992). "A novel divergently transcribed human histone H2A/H2B gene pair". DNA Seq. 1 (6): 409–13. doi:10.3109/10425179109020799. PMID 1768865.
  6. Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
  7. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  8. ^ "Entrez Gene: HIST1H2AM histone cluster 1, H2am".

Further reading

PDB gallery
  • 1aoi: COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT 1aoi: COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT
  • 1eqz: X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION 1eqz: X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION
  • 1hq3: CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE 1hq3: CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE
  • 1kx3: X-Ray Structure of the Nucleosome Core Particle, NCP146, at 2.0 A Resolution 1kx3: X-Ray Structure of the Nucleosome Core Particle, NCP146, at 2.0 A Resolution
  • 1kx4: X-Ray Structure of the Nucleosome Core Particle, NCP146b, at 2.6 A Resolution 1kx4: X-Ray Structure of the Nucleosome Core Particle, NCP146b, at 2.6 A Resolution
  • 1kx5: X-Ray Structure of the Nucleosome Core Particle, NCP147, at 1.9 A Resolution 1kx5: X-Ray Structure of the Nucleosome Core Particle, NCP147, at 1.9 A Resolution
  • 1m18: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA 1m18: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
  • 1m19: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA 1m19: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
  • 1m1a: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA 1m1a: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
  • 1p34: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p34: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3a: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3a: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3b: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3b: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3f: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3f: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3g: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3g: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3i: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3i: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3k: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3k: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3l: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3l: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3m: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3m: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3o: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3o: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1p3p: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3p: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
  • 1s32: Molecular Recognition of the Nucleosomal 'Supergroove' 1s32: Molecular Recognition of the Nucleosomal 'Supergroove'
  • 1tzy: Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution 1tzy: Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution
  • 1zbb: Structure of the 4_601_167 Tetranucleosome 1zbb: Structure of the 4_601_167 Tetranucleosome
  • 1zla: X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core 1zla: X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core
  • 2aro: Crystal Structure Of The Native Histone Octamer To 2.1 Angstrom Resolution, Crystalised In The Presence Of S-Nitrosoglutathione 2aro: Crystal Structure Of The Native Histone Octamer To 2.1 Angstrom Resolution, Crystalised In The Presence Of S-Nitrosoglutathione
  • 2cv5: Crystal structure of human nucleosome core particle 2cv5: Crystal structure of human nucleosome core particle
  • 2f8n: 2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes 2f8n: 2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes
  • 2fj7: Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element 2fj7: Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element
  • 2hio: HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN 2hio: HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN
  • 2nzd: Nucleosome core particle containing 145 bp of DNA 2nzd: Nucleosome core particle containing 145 bp of DNA


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