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Imidazothiazoles

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(Redirected from Imidazothiazole) Class of chemical compounds comprising a bicyclic heterocycle
The general structure of imidazothiazoles.

Imidazothiazoles are a class of chemical compounds containing a bicyclic heterocycle (a double ring system) consisting of an imidazole ring fused to a thiazole ring. The structure contains three non-carbon or heteroatoms: two nitrogen atoms and one sulfur atom. Imidazothiazole derivatives show a broad spectrum of in vitro, i.e. "in the petri dish", activity such as anticancer, antipsychotic, antimicrobial, antifungal, and anthelmintic (against cancer, psychosis, microorganisms, fungi and worms, respectively).

References

  1. Fascio, Mirta L.; Errea, María Inés; D'Accorso, Norma Beatriz (2015-01-27). "Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties". European Journal of Medicinal Chemistry. 90: 666–683. doi:10.1016/j.ejmech.2014.12.012. hdl:11336/17776. PMID 25499987.
  2. Gürsoy, Elif; Güzeldemirci, Nuray Ulusoy (2007-03-01). "Synthesis and primary cytotoxicity evaluation of new imidazothiazole derivatives". European Journal of Medicinal Chemistry. 42 (3): 320–326. doi:10.1016/j.ejmech.2006.10.012. PMID 17145120.
  3. Andreani, Aldo; Granaiola, Massimiliano; Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella; Varoli, Lucilla; Lannigan, Deborah; Smith, Jeff; Scudiero, Dominic; Kondapaka, Sudhir (2011-09-01). "Imidazothiazole guanylhydrazones as RSK2 inhibitors ". European Journal of Medicinal Chemistry. 46 (9): 4311–4323. doi:10.1016/j.ejmech.2011.07.001. hdl:11585/105011. PMID 21794960.
  4. Park, Jin-Hun; El-Gamal, Mohammed I.; Lee, Yong Sup; Oh, Chang-Hyun (2011-12-01). "New imidazothiazole derivatives: Synthesis, in vitro anticancer evaluation, and in silico studies". European Journal of Medicinal Chemistry. 46 (12): 5769–5777. doi:10.1016/j.ejmech.2011.08.024. PMID 22033063.
  5. Cole, Derek C.; Stock, Joseph R.; Lennox, William J.; Bernotas, Ronald C.; Ellingboe, John W.; Boikess, Steve; Coupet, Joseph; Smith, Deborah L.; Leung, Louis; Zhang, Guo-Ming; Feng, Xidong (2007-11-01). "Discovery of N1-(6-Chloroimidazothiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT6 Receptor Agonist". Journal of Medicinal Chemistry. 50 (23): 5535–5538. doi:10.1021/jm070521y. PMID 17948978.
  6. Güzeldemirci, Nuray Ulusoy; Küçükbasmacı, Ömer (2010-01-01). "Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazothiazole moiety". European Journal of Medicinal Chemistry. 45 (1): 63–68. doi:10.1016/j.ejmech.2009.09.024. PMID 19939519.
  7. Malik, Jitender K.; Soni, Himesh; Singhai, A.K. (2013-01-01). "Synthesis, characterization and evaluation for antifungal activity of substituted diaryl imidazo [2, 1, b]-benzothiazole". Journal of Pharmacy Research. 7 (1): 39–46. doi:10.1016/j.jopr.2013.01.002.
  8. Amarouch, Hamid; Loiseau, Philippe R; Bacha, Catarina; Caujolle, Raymond; Payard, Marc; Loiseau, Philippe M; Bories, Christian; Gayral, Philippe (1987-09-01). "Imidazothiazoles: analogues du lévamisole". European Journal of Medicinal Chemistry (in French). 22 (5): 463–466. doi:10.1016/0223-5234(87)90037-7.


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