Jeffress is an English surname. Notable people with the surname include:
- Gary Jeffress, American academic
- Gene Jeffress (born 1948), American politician
- Jeremy Jeffress (born 1987), American baseball pitcher
- Neville Jeffress (1920–2007), Australian advertising executive
- Robert Jeffress (born 1955), American pastor
- Steven Jeffress (born 1975), Australian golfer
- Arthur Jeffress (1905-1961), Patron of the Arts
- Michael S. Jeffress (born 1972), American Academic, Disability Studies Scholar
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