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Kallidin

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Kallidin
Names
IUPAC name L-Lysyl-L-arginyl-L-prolyl-L-prolyl-glycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.005.853 Edit this at Wikidata
IUPHAR/BPS
MeSH Kallidin
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C56H85N17O12/c57-24-8-7-18-36(58)46(76)67-37(19-9-25-63-55(59)60)51(81)73-29-13-23-44(73)53(83)72-28-11-21-42(72)49(79)65-32-45(75)66-39(30-34-14-3-1-4-15-34)47(77)70-41(33-74)52(82)71-27-12-22-43(71)50(80)69-40(31-35-16-5-2-6-17-35)48(78)68-38(54(84)85)20-10-26-64-56(61)62/h1-6,14-17,36-44,74H,7-13,18-33,57-58H2,(H,65,79)(H,66,75)(H,67,76)(H,68,78)(H,69,80)(H,70,77)(H,84,85)(H4,59,60,63)(H4,61,62,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1Key: FYSKZKQBTVLYEQ-FSLKYBNLSA-N
  • InChI=1/C56H85N17O12/c57-24-8-7-18-36(58)46(76)67-37(19-9-25-63-55(59)60)51(81)73-29-13-23-44(73)53(83)72-28-11-21-42(72)49(79)65-32-45(75)66-39(30-34-14-3-1-4-15-34)47(77)70-41(33-74)52(82)71-27-12-22-43(71)50(80)69-40(31-35-16-5-2-6-17-35)48(78)68-38(54(84)85)20-10-26-64-56(61)62/h1-6,14-17,36-44,74H,7-13,18-33,57-58H2,(H,65,79)(H,66,75)(H,67,76)(H,68,78)(H,69,80)(H,70,77)(H,84,85)(H4,59,60,63)(H4,61,62,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1Key: FYSKZKQBTVLYEQ-FSLKYBNLBR
SMILES
  • O=C(N(C(=O)N(C(=O)O)CCC/N=C(\N)N)Cc1ccccc1)5N(C(=O)(NC(=O)(NC(=O)CNC(=O)3N(C(=O)2N(C(=O)(NC(=O)(N)CCCCN)CCC/N=C(\N)N)CCC2)CCC3)Cc4ccccc4)CO)CCC5
Properties
Chemical formula C56H85N17O12
Molar mass 1188.403 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkY verify (what is  ?) Infobox references
Chemical compound

Kallidin is a bioactive kinin peptide formed in response to injury from kininogen precursors through the action of kallikreins.

Kallidin is a decapeptide whose sequence is H-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH. It can be converted to bradykinin by the aminopeptidase enzyme.

It can be a substrate for carboxypeptidase M and N.

Kallidin is identical to bradykinin with an additional lysine residue added at the N-terminal end and signals through the bradykinin receptor.

References

  1. Campbell, Duncan John (2013). "Bradykinin Peptides". Handbook of Biologically Active Peptides. pp. 1386–1393. doi:10.1016/B978-0-12-385095-9.00188-3. ISBN 978-0-12-385095-9.
  2. Herwald, Heiko; Müller-Esterl, Werner; Renné, Thomas (2008). "Kinins". Encyclopedia of Molecular Pharmacology. pp. 673–676. doi:10.1007/978-3-540-38918-7_86. ISBN 978-3-540-38916-3.
Autacoids
Kinins
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