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Long-chain-alcohol dehydrogenase

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Catalytic enzyme
long-chain-alcohol dehydrogenase
Identifiers
EC no.1.1.1.192
CAS no.76774-36-2
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In enzymology, a long-chain-alcohol dehydrogenase (EC 1.1.1.192) is an enzyme that catalyzes the chemical reaction

a long-chain alcohol + 2 NAD + H2O {\displaystyle \rightleftharpoons } a long-chain carboxylate + 2 NADH + 2 H

The 3 substrates of this enzyme are long-chain alcohol, NAD, and H2O, whereas its 3 products are long-chain carboxylate, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is long-chain-alcohol:NAD oxidoreductase. Other names in common use include long-chain alcohol dehydrogenase, and fatty alcohol oxidoreductase. This enzyme participates in fatty acid metabolism.

References

  • Lee T (April 1979). "Characterization of fatty alcohol:NAD+ oxidoreductase from rat liver". The Journal of Biological Chemistry. 254 (8): 2892–6. PMID 34610.
Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
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