| Long-chain-fatty-acid— ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.2.1.20 | ||||||||
| CAS no. | 77322-37-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a long-chain-fatty-acid— ligase (EC 6.2.1.20) is an enzyme that catalyzes the chemical reaction
- ATP + an acid + AMP + diphosphate + acyl-
AMP + diphosphate + acyl-The 3 substrates of this enzyme are ATP, acid, and acyl-carrier-protein, whereas its 3 products are AMP, diphosphate, and ]].
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is long-chain-fatty-acid: ligase (AMP-forming). Other names in common use include acyl- synthetase, acyl- synthetase, acyl-ACP synthetase, acyl-synthetase, stearoyl-ACP synthetase, and acyl-acyl carrier protein synthetase. This enzyme participates in fatty acid metabolism.
References
- Ray TK, Cronan JE (1976). "Activation of long chain fatty acids with acyl carrier protein: demonstration of a new enzyme, acyl-acyl carrier protein synthetase, in Escherichia coli". Proc. Natl. Acad. Sci. U.S.A. 73 (12): 4374–8. doi:10.1073/pnas.73.12.4374. PMC 431460. PMID 794875.
| Enzymes: CO CS and CN ligases (EC 6.1-6.3) | |
|---|---|
| 6.1: Carbon-Oxygen | |
| 6.2: Carbon-Sulfur | |
| 6.3: Carbon-Nitrogen | |
| Enzymes | |
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| Activity | |
| Regulation | |
| Classification | |
| Kinetics | |
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