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MAGI3

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Protein-coding gene in the species Homo sapiens
MAGI3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3SOE

Identifiers
AliasesMAGI3, MAGI-3, dJ730K3.2, membrane associated guanylate kinase, WW and PDZ domain containing 3
External IDsOMIM: 615943; MGI: 1923484; HomoloGene: 26431; GeneCards: MAGI3; OMA:MAGI3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)
Chromosome 1 (human)Genomic location for MAGI3Genomic location for MAGI3
Band1p13.2Start113,390,515 bp
End113,685,923 bp
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)
Chromosome 3 (mouse)Genomic location for MAGI3Genomic location for MAGI3
Band3 F2.2|3 45.52 cMStart103,920,575 bp
End104,127,690 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lower lobe of lung

  • nasal epithelium

  • mucosa of ileum

  • jejunal mucosa

  • mucosa of colon

  • palpebral conjunctiva

  • mucosa of sigmoid colon

  • corpus epididymis

  • pars compacta

  • mucosa of pharynx
Top expressed in
  • atrioventricular valve

  • globus pallidus

  • habenula

  • superior colliculus

  • dorsal tegmental nucleus

  • left lung lobe

  • medial vestibular nucleus

  • ventral tegmental area

  • ciliary body

  • piriform cortex
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

260425

99470

Ensembl

ENSG00000081026

ENSMUSG00000052539

UniProt

Q5TCQ9

Q9EQJ9

RefSeq (mRNA)

NM_001142782
NM_020965
NM_152900

NM_001159354
NM_133853

RefSeq (protein)

NP_001136254
NP_690864
NP_690864.2

NP_001152826
NP_598614

Location (UCSC)Chr 1: 113.39 – 113.69 MbChr 3: 103.92 – 104.13 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 is an enzyme that in humans is encoded by the MAGI3 gene.


Interactions

MAGI3 has been shown to interact with PTPRB and PTEN.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000081026Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000052539Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
  6. ^ Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q, Lasky LA (Aug 2000). "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase". J Biol Chem. 275 (28): 21477–85. doi:10.1074/jbc.M909741199. PMID 10748157.
  7. "Entrez Gene: MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3".
  8. Adamsky, Konstantin; Arnold Katya; Sabanay Helena; Peles Elior (Apr 2003). "Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins". J. Cell Sci. 116 (Pt 7): 1279–89. doi:10.1242/jcs.00302. ISSN 0021-9533. PMID 12615970.

Further reading


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