MHC may refer to:
Biology
- Major histocompatibility complex, a highly polymorphic region on chromosome 6 with genes particularly involved in immune functions
- Myosin heavy chain, part of the motor protein myosin's quaternary protein structure
Colleges
- Mars Hill College (now Mars Hill University), a college in Mars Hill, North Carolina, USA
- Mount Holyoke College, a college in South Hadley, Massachusetts, USA
- William E. Macaulay Honors College, an honors college within the City University of New York
Health
- Managed health care
- Mental health counselor
- Metropolitan Hospital Center, East Harlem, New York City
Sports
- Malaysian Hockey Confederation
- Mediterranean Handball Confederation
- Mid Hudson Conference
- Milwaukee Hurling Club
Other
- Maimonides Heritage Center
- Massachusetts Historical Commission
- Mile High City, common nickname for the city of Denver, Colorado, due to its elevation of exactly one mile above sea level
- Mile high club
- Mochoʼ language (ISO 639:mhc), a moribund Mayan language spoken in Chiapas, Mexico
- Mocopulli Airport (IATA: MHC), Dalcahue, Los Lagos, Chile
- Model of hierarchical complexity
- Mohawk–Hudson convergence, a meteorological phenomenon
- Murphy-Hoffman Company
- Museum of the History of Catalonia
- A US Navy hull classification symbol: Coastal minehunter (MHC)
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