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MOB4
Identifiers
Aliases	MOB4, 2C4D, MOB1, MOB3, MOBKL3, PHOCN, PREI3, CGI-95, MOB family member 4, phocein
External IDs	OMIM: 609361; MGI: 104899; HomoloGene: 9116; GeneCards: MOB4; OMA:MOB4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q33.1 Start 197,515,571 bp End 197,553,699 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C1.2 Start 55,170,390 bp End 55,194,058 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of biceps brachii right ventricle thoracic diaphragm deltoid muscle Skeletal muscle tissue of rectus abdominis vastus lateralis muscle myocardium triceps brachii muscle tibialis anterior muscle myocardium of left ventricle Top expressed in adrenal gland interventricular septum medial ganglionic eminence parotid gland left lung lobe migratory enteric neural crest cell vas deferens vastus lateralis muscle atrioventricular valve abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding kinase binding Cellular component cytoplasm perinuclear region of cytoplasm Golgi cisterna membrane Golgi apparatus membrane cytosol soma dendritic spine Biological process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25843 19070 Ensembl ENSG00000115540 ENSMUSG00000025979 UniProt Q9Y3A3 Q6PEB6 RefSeq (mRNA) NM_199482 NM_001100819 NM_001204094 NM_015387 NM_025283 NM_001310585 RefSeq (protein) NP_001094289 NP_001191023 NP_056202 NP_955776 NP_001297514 NP_079559 Location (UCSC) Chr 2: 197.52 – 197.55 Mb Chr 1: 55.17 – 55.19 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Mps one binder kinase activator-like 3 is an enzyme that in humans is encoded by the MOBKL3 gene.

Function

This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Interactions

MOBKL3 has been shown to interact with:

• CTTNBP2NL,
• CTTNBP2,
• FAM40A,
• PDCD10,
• PPP2CA,
• RP6-213H19.1,
• STK24,
• STK25,
• STRN3,
• STRN, and
• TRAF3IP3.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000115540 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000025979 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
7. Moreno CS, Lane WS, Pallas DC (Jun 2001). "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes". The Journal of Biological Chemistry. 276 (26): 24253–60. doi:10.1074/jbc.M102398200. PMC 3503316. PMID 11319234.
8. ^ "Entrez Gene: PREI3 preimplantation protein 3".
9. ^ Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
10. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

• Baillat G, Gaillard S, Castets F, Monneron A (May 2002). "Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I". The Journal of Biological Chemistry. 277 (21): 18961–6. doi:10.1074/jbc.M108818200. PMID 11872741.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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