Mattei is a surname. Notable people with the surname include:
- Members of the Mattei family of Italian nobility including:
- Muzio Mattei
- Ciriaco Mattei (Muzio's nephew)
- Girolamo Mattei (Ciriaco's brother and a cardinal)
- Asdrubale Mattei (Ciriaco's brother)
- Girolamo Mattei, Duca di Giove (Asdrubale's son)
- Luigi Mattei (Asdrubale's son)
- Muzio Mattei
- Bruno Mattei, Italian movie director
- Enrico Mattei, Italian public administrator who created ENI
- Fernando Matthei, Chilean airforce commander and junta member
- Evelyn Matthei, Chilean right-wing politician
- Janet Akyüz Mattei (1943–2004), Turkish-American astronomer and former director of the American Association of Variable Star Observers
- Ugo Mattei, professor at the University of Torino
- Olga Elena Mattei, Colombian Poet
- Peter Mattei, Swedish operatic baritone
- Stanislao Mattei, composer and priest
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