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Monocarboxylate transporter 6

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Protein-coding gene in the species Homo sapiens
SLC16A5
Identifiers
AliasesSLC16A5, MCT5, MCT6, solute carrier family 16 member 5, Monocarboxylate transporter 6
External IDsOMIM: 603879; MGI: 2443515; HomoloGene: 20985; GeneCards: SLC16A5; OMA:SLC16A5 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)
Chromosome 17 (human)Genomic location for SLC16A5Genomic location for SLC16A5
Band17q25.1Start75,087,727 bp
End75,106,162 bp
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)
Chromosome 11 (mouse)Genomic location for SLC16A5Genomic location for SLC16A5
Band11|11 E2Start115,353,300 bp
End115,365,224 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • mucosa of transverse colon

  • right uterine tube

  • pancreatic ductal cell

  • upper lobe of left lung

  • oocyte

  • duodenum

  • right lung

  • epithelium of nasopharynx

  • monocyte
Top expressed in
  • thymus

  • jejunum

  • right kidney

  • duodenum

  • epithelium of stomach

  • colon

  • left colon

  • embryo

  • human kidney

  • ileum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9121

217316

Ensembl

ENSG00000170190

ENSMUSG00000045775

UniProt

O15375

G5E8K6

RefSeq (mRNA)

NM_001271765
NM_004695
NM_001369668

NM_001080934
NM_001359606
NM_001359608
NM_001359609

RefSeq (protein)

NP_001258694
NP_004686
NP_001356597

NP_001074403
NP_001346535
NP_001346537
NP_001346538

Location (UCSC)Chr 17: 75.09 – 75.11 MbChr 11: 115.35 – 115.37 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Monocarboxylate transporter 6 (MCT6) is a protein in humans that is encoded by the SLC16A5 gene.

This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. .

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000170190Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000045775Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Solute carrier family 16, member 5 (monocarboxylic acid transporter 6)".


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