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Nitrite reductase (NAD(P)H)

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Class of enzymes
nitrite reductase
Identifiers
EC no.1.7.1.4
CAS no.9029-29-2
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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In enzymology, a nitrite reductase (EC 1.7.1.4) is an enzyme that catalyzes the chemical reaction

ammonium hydroxide + 3 NAD(P) + H2O {\displaystyle \rightleftharpoons } nitrite + 3 NAD(P)H + 3 H

The 4 substrates of this enzyme are ammonium hydroxide, NAD, NADP, and H2O, whereas its 4 products are nitrite, NADH, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ammonium-hydroxide:NAD(P)+ oxidoreductase. Other names in common use include nitrite reductase (reduced nicotinamide adenine dinucleotide, (phosphate)), NADH-nitrite oxidoreductase, NADPH-nitrite reductase, assimilatory nitrite reductase, nitrite reductase , and NAD(P)H2:nitrite oxidoreductase. This enzyme participates in nitrogen metabolism. It has 3 cofactors: FAD, Iron, and Siroheme.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JO6.

References

Oxidoreductases: nitrogenous donor (EC 1.7)
1.7.1
1.7.2
1.7.3
1.7.7
1.7.99
Enzymes
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Regulation
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