O-phospho-L-serine—tRNA ligase

O-phospho-L-serine—tRNA ligase (EC 6.1.1.27, O-phosphoseryl-tRNA ligase, non-canonical O-phosphoseryl-tRNA synthetase, SepRS) is an enzyme with systematic name O-phospho-L-serine:tRNACys ligase (AMP-forming). This enzyme catalyses the following chemical reaction:

ATP + O-phospho-L-serine + tRNACys

\rightleftharpoons

AMP + diphosphate + O-phospho-L-seryl-tRNACys

In organisms like Archaeoglobus fulgidus, this enzyme ligates O-phosphoserine to tRNACys.

References

Fukunaga R, Yokoyama S (April 2007). "Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea". Nature Structural & Molecular Biology. 14 (4): 272–9. doi:10.1038/nsmb1219. PMID 17351629. S2CID 10959763.
Hauenstein SI, Perona JJ (August 2008). "Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei". The Journal of Biological Chemistry. 283 (32): 22007–17. doi:10.1074/jbc.M801839200. PMC 2494925. PMID 18559341.

External links

O-phospho-L-serine—tRNA+ligase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Enzymes: CO CS and CN ligases (EC 6.1-6.3)
6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanine Arginine Asparagine Aspartate Cysteine D-alanine—poly(phosphoribitol) ligase Glutamate Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine
6.2: Carbon-Sulfur	Succinyl coenzyme A synthetase Acetyl—CoA synthetase Long-chain-fatty-acid—CoA ligase
6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 6.1.1