Osipenko (Russian), Osypenko (Ukrainian), or Asipenka (Belarusian) may refer to:
People
- Alla Osipenko (b. 1932), Russian ballerina
- Alexander Osipenko (1910–1991), Soviet Lieutenant-General
- Polina Osipenko (1907–1939), Soviet pilot, Hero of the Soviet Union
- Inna Osypenko (b. 1982), Ukrainian sprint canoer
- Dzmitry Asipenka (b. 1982), Belarusian soccer player
Populated places in Ukraine
- Osypenko, Solone Raion, a village, Dnipropetrovsk Oblast, Ukraine
- Osypenko, Berdyansk Raion, a village, Zaporizhia Oblast, Ukraine
- Osypenko, Sevastopol, a village under the jurisdiction of the city of Sevastopol, Ukraine
- Osypenko, name of the town of Berdyansk, Ukraine, in 1939–1958
See also
- Imeni Poliny Osipenko District, a district of Khabarovsk Krai, Russia
- Imeni Poliny Osipenko (rural locality), a rural locality (a selo), the administrative center of that district
- Poliny Osipenko Street, name of Sadovnicheskaya Street, Moscow, Russia, in 1939–1991
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