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In enzymology, a phenylacetyl-CoA dehydrogenase (EC 1.17.5.1) is an enzyme that catalyzes the chemical reaction

phenylacetyl-CoA + H₂O + 2 quinone ${\displaystyle \rightleftharpoons }$ phenylglyoxylyl-CoA + 2 quinol

The 3 substrates of this enzyme are phenylacetyl-CoA, H₂O, and quinone, whereas its two products are phenylglyoxylyl-CoA and quinol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH₂ groups with a quinone or similar compound as acceptor. The systematic name of this enzyme class is phenylacetyl-CoA:quinone oxidoreductase. This enzyme is also called phenylacetyl-CoA:acceptor oxidoreductase.

References

• Rhee SK, Fuchs G (1999). "Phenylacetyl-CoA:acceptor oxidoreductase, a membrane-bound molybdenum–iron–sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica". Eur. J. Biochem. 262 (2): 507–15. doi:10.1046/j.1432-1327.1999.00399.x. PMID 10336636.
• Schneider S, Fuchs G (1998). "Phenylacetyl-CoA:acceptor oxidoreductase, a new α-oxidizing enzyme that produces phenylglyoxylate. Assay, membrane localization, and differential production in Thauera aromatica". Arch. Microbiol. 169 (6): 509–16. doi:10.1007/s002030050604. PMID 9575237.

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