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Polyprenyl synthetases are a class of enzymes responsible for synthesis of isoprenoids. Isoprenoid compounds are synthesized by various organisms. For example, in eukaryotes the isoprenoid biosynthetic pathway is responsible for the synthesis of a variety of end products including cholesterol, dolichol, ubiquinone or coenzyme Q. In bacteria this pathway leads to the synthesis of isopentenyl tRNA, isoprenoid quinones, and sugar carrier lipids. Among the enzymes that participate in that pathway, are a number of polyprenyl synthetase enzymes which catalyze a 1'4-condensation between 5-carbon isoprene units. It has been shown that all the above enzymes share some regions of sequence similarity. Two of these regions are rich in aspartic-acid residues and could be involved in the catalyticmechanism and/or the binding of the substrates.
Fujisaki S, Hara H, Nishimura Y, Horiuchi K, Nishino T (December 1990). "Cloning and nucleotide sequence of the ispA gene responsible for farnesyl diphosphate synthase activity in Escherichia coli". J. Biochem. 108 (6): 995–1000. doi:10.1093/oxfordjournals.jbchem.a123327. PMID2089044.
Kuntz M; Römer S; Suire C; Hugueney P; Weil JH; Schantz R; Camara B (January 1992). "Identification of a cDNA for the plastid-located geranylgeranyl pyrophosphate synthase from Capsicum annuum: correlative increase in enzyme activity and transcript level during fruit ripening". Plant J. 2 (1): 25–34. doi:10.1046/j.1365-313x.1992.t01-47-00999.x. PMID1303794.
active conformation of farnesyl pyrophosphate synthase bound to isopentyl pyrophosphate and dimethylallyl s-thiolodiphosphate