Prosolanapyrone-III cycloisomerase

Prosolanapyrone-III cycloisomerase (EC 5.5.1.20, Sol5, SPS, solanapyrone synthase (bifunctional enzyme: prosolanapyrone II oxidase/prosolanapyrone III cyclosiomerase)) is an enzyme with systematic name prosolanapyrone-III:(-)-solanapyrone A isomerase. This enzyme catalyses the following chemical reaction

prosolanapyrone III

\rightleftharpoons

(-)-solanapyrone A

The enzyme is involved in the biosynthesis of the phytotoxin solanapyrone in some fungi.

References

Kasahara K, Miyamoto T, Fujimoto T, Oguri H, Tokiwano T, Oikawa H, Ebizuka Y, Fujii I (June 2010). "Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani". ChemBioChem. 11 (9): 1245–52. doi:10.1002/cbic.201000173. PMID 20486243.
Katayama K, Kobayashi T, Oikawa H, Honma M, Ichihara A (May 1998). "Enzymatic activity and partial purification of solanapyrone synthase: first enzyme catalyzing Diels-Alder reaction". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1384 (2): 387–95. doi:10.1016/s0167-4838(98)00040-5. PMID 9659400.
Katayama K, Kobayashi T, Chijimatsu M, Ichihara A, Oikawa H (February 2008). "Purification and N-terminal amino acid sequence of solanapyrone synthase, a natural Diels-Alderase from Alternaria solani". Bioscience, Biotechnology, and Biochemistry. 72 (2): 604–7. doi:10.1271/bbb.70600. PMID 18256508.

External links

Prosolanapyrone-III+cycloisomerase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Isomerase: Intramolecular Lyases (EC 5.5)
5.5.1 Intramolecular Lyases	muconate cycloisomerase 3-carboxy-cis,cis-muconate cycloisomerase tetrahydroxypteridine cycloisomerase inositol-3-phosphate synthase carboxy-cis,cis-muconate cyclase chalcone isomerase chloromuconate cycloisomerase bornyl diphosphate synthase cycloeucalenol cycloisomerase a-pinene-oxide decyclase dichloromuconate cycloisomerase copalyl diphosphate synthase ent-copalyl diphosphate synthase syn-copalyl-diphosphate synthase terpentedienyl-diphosphate synthase halimadienyl-diphosphate synthase (S)-beta-macrocarpene synthase lycopene epsilon-cyclase lycopene beta-cyclase prosolanapyrone-III cycloisomerase

Isomerase: Intramolecular Lyases (EC 5.5)

5.5.1 Intramolecular Lyases

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 5.5.1