Pyroglutamyl-peptidase II

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Pyroglutamyl-peptidase II (EC 3.4.19.6, thyroliberinase, pyroglutamyl aminopeptidase II, thyrotropin-releasing factor pyroglutamate aminopeptidase, pyroglutamate aminopeptidase II, pyroglutamyl peptidase II, thyroliberin-hydrolyzing pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading peptidase, TRH aminopeptidase) is an enzyme. This enzyme catalyses the following chemical reaction

Release of the N-terminal pyroglutamyl group from pGlu--His-Xaa tripeptides and pGlu--His-Xaa-Gly tetrapeptides

This enzyme is highly specific for thyrotropin releasing hormone.

Human gene

TRHDE - thyrotropin releasing hormone degrading enzyme

References

Bauer K, Nowak P (September 1979). "Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond". European Journal of Biochemistry. 99 (2): 239–46. doi:10.1111/j.1432-1033.1979.tb13250.x. PMID 115687.
O'Connor B, O'Cuinn G (July 1985). "Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain". European Journal of Biochemistry. 150 (1): 47–52. doi:10.1111/j.1432-1033.1985.tb08986.x. PMID 2862039.
Wilk, S.; Wilk, E.K. (1989). "Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme". Neurochem. Int. 15: 81–89. doi:10.1016/0197-0186(89)90079-x.

External links

Pyroglutamyl-peptidase+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: proteases (EC 3.4)

3.4.11-19: Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O
3.4.13	Dipeptidase 1 2 3
3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II
3.4.15	Angiotensin-converting enzyme
3.4.16	Serine type carboxypeptidases: Cathepsin A DD-Transpeptidase
3.4.17	Metalloexopeptidases Carboxypeptidase A A2 B C E Glutamate II
Other/ungrouped	Metalloexopeptidase

3.4.21-25: Endopeptidase

Other/ungrouped: Amyloid precursor protein secretase

3.4.99: Unknown

Staphylokinase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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EC 3.4.19