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RASD2
Identifiers
Aliases	RASD2, MGC:4834, Rhes, TEM2, RASD family member 2
External IDs	OMIM: 612842; MGI: 1922391; HomoloGene: 8628; GeneCards: RASD2; OMA:RASD2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q12.3 Start 35,540,831 bp End 35,553,999 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 C1 Start 75,940,572 bp End 75,950,741 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in putamen caudate nucleus nucleus accumbens right frontal lobe muscle layer of sigmoid colon apex of heart prefrontal cortex Brodmann area 9 cingulate gyrus anterior cingulate cortex Top expressed in superior frontal gyrus dorsal striatum nucleus accumbens visual cortex primary visual cortex muscle of thigh nucleus of stria terminalis dentate gyrus of hippocampal formation granule cell olfactory tubercle substantia nigra More reference expression data BioGPS n/a
Gene ontology Molecular function G-protein beta-subunit binding nucleotide binding GTP binding ubiquitin conjugating enzyme binding phosphatidylinositol 3-kinase binding GTPase activity Cellular component plasma membrane membrane Biological process negative regulation of protein ubiquitination regulation of cAMP-mediated signaling positive regulation of protein kinase B signaling synaptic transmission, dopaminergic positive regulation of protein sumoylation locomotory behavior signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23551 75141 Ensembl ENSG00000100302 ENSMUSG00000034472 UniProt Q96D21 P63032 RefSeq (mRNA) NM_014310 NM_001366725 NM_001376515 NM_001376516 NM_029182 RefSeq (protein) NP_055125 NP_001353654 NP_001363444 NP_001363445 NP_083458 Location (UCSC) Chr 22: 35.54 – 35.55 Mb Chr 8: 75.94 – 75.95 Mb PubMed search
Wikidata
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GTP-binding protein Rhes is a protein that in humans is encoded by the RASD2 gene.

This gene encodes a Ras-related protein that is produced largely in the striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000100302 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000034472 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science. 289 (5482): 1197–202. Bibcode:2000Sci...289.1197S. doi:10.1126/science.289.5482.1197. PMID 10947988.
6. Falk JD, Vargiu P, Foye PE, Usui H, Perez J, Danielson PE, Lerner DL, Bernal J, Sutcliffe JG (Oct 1999). "Rhes: A striatal-specific Ras homolog related to Dexras1". J Neurosci Res. 57 (6): 782–8. doi:10.1002/(SICI)1097-4547(19990915)57:6<782::AID-JNR3>3.0.CO;2-9. PMID 10467249. S2CID 21124545.
7. Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P, Bernal J (Jan 2004). "The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors". Oncogene. 23 (2): 559–68. doi:10.1038/sj.onc.1207161. PMID 14724584.
8. ^ "Entrez Gene: RASD2 RASD family, member 2".

Further reading

• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Chan SL, Monks LK, Gao H, et al. (2002). "Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic β-cell". Br. J. Pharmacol. 136 (1): 31–6. doi:10.1038/sj.bjp.0704680. PMC 1762110. PMID 11976265.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Taylor JP, Jackson DA, Morgan NG, Chan SL (2006). "Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process". Biochem. Biophys. Res. Commun. 349 (2): 809–15. doi:10.1016/j.bbrc.2006.08.102. PMID 16945334.
• Agretti P, De Marco G, Pinchera A, et al. (2007). "Ras homolog enriched in striatum inhibits the functional activity of wild type thyrotropin, follicle-stimulating hormone, luteinizing hormone receptors and activating thyrotropin receptor mutations by altering their expression in COS-7 cells". J. Endocrinol. Invest. 30 (4): 279–84. doi:10.1007/bf03346294. PMID 17556863. S2CID 38877975.

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