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The positive replication error phenotype (RER+) defines a subgroup of tumors that have been documented well in Hereditary nonpolyposis colorectal cancer (HNPCC). More recently, this phenotype also has been described in breast carcinoma and is a predictor of metastases.
References
- Chagpar, Anees; Magliocco, Anthony; Kerviche, Annette; Tan, Leonard; Walley, Barbara; DeCoteau, John F. (1 March 2004). "The replication error phenotype is associated with the development of distant metastases in hormonally treated patients with breast carcinoma". Cancer. 100 (5): 913–919. doi:10.1002/cncr.20084. PMID 14983485. S2CID 25814306. INIST 15484040.
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