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Ribulose 5-phosphate

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Ribulose 5-phosphate
Names
IUPAC name
  • D-Ribulose 5-phosphate
  • 5-O-Phosphono-D-ribulose
Systematic IUPAC name dihydrogen phosphate
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChemSpider
MeSH ribulose+5-phosphate
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1Key: FNZLKVNUWIIPSJ-UHNVWZDZSA-L
  • InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1Key: FNZLKVNUWIIPSJ-DAZPBWGKBO
SMILES
  • C(((C(=O)CO)O)O)OP(=O)(O)O
Properties
Chemical formula C5H11O8P
Molar mass 230.109 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Ribulose 5-phosphate is one of the end-products of the pentose phosphate pathway. It is also an intermediate in the Calvin cycle.

It is formed by phosphogluconate dehydrogenase in the pentose phosphate pathway. Ribulose 5-phosphate is involved in various metabolic pathways. Ribulose 5-phosphate can be acted upon by phosphopentose isomerase to form ribose 5-phosphate, which is a precursor for nucleotide and co-factor biosynthesis. Ribulose-5 phosphate can also be acted upon by phosphopentose epimerase to form xylulose 5-phosphate, which is used in the nonoxidative phase of the pentose phosphate pathway in humans to generate precursor molecules for the synthesis of aromatic amino acids and production of energy.

In plants, ribulose 5-phosphate produced from the pentose-phosphate pathway is converted into ribulose-1,5-bisphosphate by the enzyme phosphoribokinase.

See also

References

  1. ^ Edwards, Thomas E.; Abramov, Ariel B.; Smith, Eric R.; Baydo, Ruth O.; Leonard, Jess T.; Leibly, David J.; Thompkins, Kaitlin B.; Clifton, Matthew C.; Gardberg, Anna S.; Staker, Bart L.; Van Voorhis, Wesley C.; Myler, Peter J.; Stewart, Lance J. (2011-10-13). "Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis". BMC Structural Biology. 11: 39. doi:10.1186/1472-6807-11-39. ISSN 1472-6807. PMC 3212906. PMID 21995815.
  2. ^ Liang, Wenguang; Ouyang, Songying; Shaw, Neil; Joachimiak, Andrzej; Zhang, Rongguang; Liu, Zhi-Jie (2010-10-05). "Conversion of<scp>d</scp>-ribulose 5-phosphate to<scp>D</scp>-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE". The FASEB Journal. 25 (2): 497–504. doi:10.1096/fj.10-171207. ISSN 0892-6638. PMC 6188353. PMID 20923965.
Pentose phosphate pathway metabolic intermediates
Oxidative
Nonoxidative
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