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Sca-1

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For the neurodegenerative disorder, see spinocerebellar ataxia type 1.

Sca-1 stands for "Stem cells antigen-1" (official gene symbol: Ly6a). It consist of 18-kDa mouse glycosyl phosphatidylinositol-anchored cell surface protein (GPI-AP) of the LY6 gene family. It is the common biological marker used to identify hematopoietic stem cell (HSC) along with other markers.

Application of Sca-1

Sca-1 has a regenerative role in cardiac repair: Host cells with specific Sca-1+CD31− markers arise upon myocardial infarction, with evidence of expression of Sca-1 protein.
Sca-1 plays a role in hematopoietic progenitor/stem cell lineage fate and c-kit expression.

References

Holmes, Christina; Stanford, William L. (June 2007). "Concise Review: Stem Cell Antigen-1: Expression, Function, and Enigma". Stem Cells. 25 (6): 1339–1347. doi:10.1634/stemcells.2006-0644. PMID 17379763. S2CID 6514438.
Wang, X; Hu, Q; Nakamura, Y; Lee, J; Zhang, G; From, AH; Zhang, J (2006). "The role of the sca-1+/CD31- cardiac progenitor cell population in postinfarction left ventricular remodeling". Stem Cells. 24 (7): 1779–1788. doi:10.1634/stemcells.2005-0386. PMID 16614004.
Bradfute, Steven B.; Graubert, Timothy A.; Goodell, Margaret A. (July 2005). "Roles of Sca-1 in hematopoietic stem/progenitor cell function". Experimental Hematology. 33 (7): 836–843. doi:10.1016/j.exphem.2005.04.001. PMID 15963860.

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