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Selenophos

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Selenophos
Names
Preferred IUPAC name Se- O-ethyl ethylphosphonoselenoate
Other names Seleno-VE
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
PubChem CID
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C10H24NO2PSe/c1-5-11(6-2)9-10-15-14(12,8-4)13-7-3/h5-10H2,1-4H3Key: QNGZOSUHNXJPIY-UHFFFAOYSA-N
SMILES
  • CCN(CC)CCP(=O)(CC)OCC
Properties
Chemical formula C10H24NO2PSe
Molar mass 300.252 g·mol
Hazards
Lethal dose or concentration (LD, LC):
LD50 (median dose) 21 μg/kg (mouse, subcutaneous)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Selenophos is an extremely potent organophosphate acetylcholinesterase inhibitor. It is the selenium analog of the VE nerve agent.

See also

References

  1. Nachmansohn, David (1 July 1969). "Proteins of Excitable Membranes". The Journal of General Physiology. 54 (1): 187–224. doi:10.1085/jgp.54.1.187. PMC 2225914. PMID 19873642.
  2. Mager, Peter P. (1984). Multidimensional pharmacochemistry : design of safer drugs. Orlando: Academic Press. p. 354. ISBN 978-0-12-465020-6.
  3. Akerfeldt, Stig.; Fagerlind, Lars. (January 1967). "Selenophosphorus Compounds as Powerful Cholinesterase Inhibitors". Journal of Medicinal Chemistry. 10 (1): 115–116. doi:10.1021/jm00313a032. PMID 6031689.
Acetylcholine metabolism and transport modulators
Enzyme
(modulators)
ChATTooltip Choline acetyltransferase
AChETooltip Acetylcholinesterase
BChETooltip Butyrylcholinesterase
Transporter
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CHTTooltip Choline transporter
VAChTTooltip Vesicular acetylcholine transporter
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Muscarinic acetylcholine receptor modulators
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