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Simplex may refer to:

Biology

• List of species named simplex, a common species name
• Herpes simplex, a viral disease caused by Herpes simplex viruses

Companies and branded products

• Simplex (bicycle), a French bicycle derailleur brand
• Simplex Manufacturing Corporation, an American manufacturer of motorcycles in Louisiana from 1935 to 1975
• American Simplex, an American automobile made in Mishawaka, Indiana, US
• Simplex Automobile Company, a defunct luxury car manufacturer from 1907 to 1921
• Crane-Simplex, a defunct luxury car manufacturer in New York, US at the start of the 20th century
• Sheffield-Simplex, a British vehicle manufacturer operating 1907–1920
• Bergmann Simplex, an early 20th-century, German-made handgun
• Mercedes Simplex, an automobile model produced between 1902 and 1909
• Simplex Typewriter Company, an index typewriter manufacturer
• A trade name used by British railway locomotive manufacturers The Motor Rail & Tramcar Co Ltd
• The trade name of the swinging-tray record changer used in Wurlitzer jukeboxes from the 1930s to the 1950s
• A brand of fire alarm systems made by SimplexGrinnell
• A manufacturer of jacks used in railroads and mining industries, now owned by Actuant Corporation

Linguistics

• A monomorphemic form of a word that is not a part of a compound or derivational affixes

Mathematics

• Simplex, a term in geometry meaning an n-dimensional analogue of a triangle
  • Simplicial polytope, a polytope with all simplex facets
  • Simplicial complex, a collection of simplicies
• Pascal's simplex, a version of Pascal's triangle of more than three dimensions
• Simplex algorithm, a popular algorithm for numerical solution of linear programming problems
• Simplex graph, derived from the cliques of another graph
• Simplex noise, a method for constructing an n-dimensional noise function
• Simplex plot, a ternary plot used in game theory

Technology

• Simplex communication, a one-way communications channel
• Simplex signaling, signalling in which two conductors are used for a single channel
• Simplex, using a single frequency for transmit and receive instead of an amateur radio repeater
• SimpleX Messaging Protocol, a privacy focused messaging protocol. See it in the Comparison of instant messaging protocols
• Simplex printing, printing one sided pages, a technique that is contrast to duplex printing
• Small Innovative Missions for Planetary Exploration (SIMPLEx) program at NASA

• Disambiguation pages