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Sodium/myo-inositol cotransporter

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Protein-coding gene in the species Homo sapiens
SLC5A3
Identifiers
AliasesSLC5A3, BCW2, SMIT, SMIT1, SMIT2, solute carrier family 5 member 3
External IDsOMIM: 600444; MGI: 1858226; HomoloGene: 31412; GeneCards: SLC5A3; OMA:SLC5A3 - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)
Chromosome 21 (human)Genomic location for SLC5A3Genomic location for SLC5A3
Band21q22.11Start34,073,578 bp
End34,106,260 bp
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)
Chromosome 16 (mouse)Genomic location for SLC5A3Genomic location for SLC5A3
Band16|16 C4Start91,855,210 bp
End91,884,361 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • renal medulla

  • Epithelium of choroid plexus

  • tibia

  • cartilage tissue

  • retinal pigment epithelium

  • trabecular bone

  • trigeminal ganglion

  • spinal ganglia

  • visceral pleura

  • mucosa of paranasal sinus
Top expressed in
  • vestibular membrane of cochlear duct

  • ciliary body

  • iris

  • Epithelium of choroid plexus

  • vestibular sensory epithelium

  • calvaria

  • sciatic nerve

  • pineal gland

  • endothelial cell of lymphatic vessel

  • retinal pigment epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6526

53881

Ensembl

ENSG00000198743

ENSMUSG00000089774

UniProt

P53794

Q9JKZ2

RefSeq (mRNA)

NM_006933

NM_017391

RefSeq (protein)

n/a

NP_059087

Location (UCSC)Chr 21: 34.07 – 34.11 MbChr 16: 91.86 – 91.88 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Sodium/myo-inositol cotransporter is a protein that in humans is encoded by the SLC5A3 gene.

Expression of the myo-inositol transport protein is regulated by osmotic stress.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000198743 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000089774 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Berry GT, Mallee JJ, Kwon HM, Rim JS, Mulla WR, Muenke M, Spinner NB (Jul 1995). "The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21". Genomics. 25 (2): 507–13. doi:10.1016/0888-7543(95)80052-N. PMID 7789985.
  6. "Entrez Gene: SLC5A3 solute carrier family 5 (inositol transporters), member 3".
  7. Lee SD, Choi SY, Lim SW, Lamitina ST, Ho SN, Go WY, Kwon HM (2011). "TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: Organic osmolyte-dependent and -independent pathways". AJP: Renal Physiology. 300 (3): F707 – F715. doi:10.1152/ajprenal.00227.2010. PMC 3064130. PMID 21209002.

Further reading

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
By group
SLC1–10
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SLC11–20
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SLC21–30
(21):
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SLC31–40
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SLC41–48
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SLCO1–4
Ion pumps
Symporter, Cotransporter
Antiporter (exchanger)
see also solute carrier disorders


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