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TXNDC2
Identifiers
Aliases	TXNDC2, SPTRX, SPTRX1, thioredoxin domain containing 2
External IDs	OMIM: 617790; MGI: 2389312; HomoloGene: 41856; GeneCards: TXNDC2; OMA:TXNDC2 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) Band 18p11.22 Start 9,885,766 bp End 9,889,275 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 E1.1 Start 65,944,502 bp End 65,949,163 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm testicle gonad brain stem muscle tissue Medulla Oblongata stromal cell of endometrium upper respiratory tract Top expressed in seminiferous tubule zygote primary oocyte secondary oocyte spermatid paraventricular nucleus of hypothalamus spermatocyte adrenal gland embryo ovary More reference expression data BioGPS n/a
Gene ontology Molecular function protein-disulfide reductase activity thioredoxin-disulfide reductase activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor protein-disulfide reductase (NAD(P)) activity Cellular component cytoplasm Biological process multicellular organism development cellular response to oxidative stress cell differentiation glycerol ether metabolic process cell redox homeostasis spermatogenesis cellular oxidant detoxification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84203 213272 Ensembl ENSG00000168454 ENSMUSG00000050612 UniProt Q86VQ3 Q6P902 RefSeq (mRNA) NM_032243 NM_001098529 NM_001146002 NM_153519 RefSeq (protein) NP_001091999 NP_115619 NP_001139474 NP_705739 NP_001391021 NP_001391027 Location (UCSC) Chr 18: 9.89 – 9.89 Mb Chr 17: 65.94 – 65.95 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Thioredoxin domain-containing protein 2 is a protein that in humans is encoded by the TXNDC2 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000168454 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000050612 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. Miranda-Vizuete A, Ljung J, Damdimopoulos AE, Gustafsson JA, Oko R, Pelto-Huikko M, Spyrou G (Aug 2001). "Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa" (PDF). J Biol Chem. 276 (34): 31567–74. doi:10.1074/jbc.M101760200. PMID 11399755. S2CID 8214150.
7. "Entrez Gene: TXNDC2 thioredoxin domain containing 2 (spermatozoa)".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jiménez A, Johansson C, Ljung J, et al. (2002). "Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity". FEBS Lett. 530 (1–3): 79–84. Bibcode:2002FEBSL.530...79J. doi:10.1016/S0014-5793(02)03417-8. hdl:10261/47334. PMID 12387870. S2CID 24685421.
• Sadek CM, Damdimopoulos AE, Pelto-Huikko M, et al. (2002). "Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells". Genes Cells. 6 (12): 1077–90. doi:10.1046/j.1365-2443.2001.00484.x. hdl:10261/47418. PMID 11737268. S2CID 20869820.

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